Buller A J, Pope R
Philos Trans R Soc Lond B Biol Sci. 1977 Apr 26;278(961):295-305. doi: 10.1098/rstb.1977.0043.
While it has been recognized for many years that different limb muscles belonging to the same mammal may have markedly differing contractile characteristics, it is only comparatively recently that it has been demonstrated that these differences depend upon the motor innervation. By appropriately changing the peripheral nerve innervating a mammalian skeletal muscle, it is possible to change dramatically the contractile behaviour of the reinnervated muscle. The manner by which the motor innervation determines the nature of a muscle fibre's contractile machinery is not completely understood, but it appears that the number and pattern of motor nerve impulses reaching the muscle play an important role. The biochemical changes occurring within muscle fibres whose contractile properties have been modified by altered motor innervation include the synthesis of different contractile proteins.
多年来人们已经认识到，同一哺乳动物的不同肢体肌肉可能具有明显不同的收缩特性，但直到最近才证明这些差异取决于运动神经支配。通过适当地改变支配哺乳动物骨骼肌的外周神经，有可能显著改变重新支配的肌肉的收缩行为。运动神经支配决定肌肉纤维收缩机制性质的方式尚未完全了解，但到达肌肉的运动神经冲动的数量和模式似乎起着重要作用。其收缩特性因运动神经支配改变而发生改变的肌肉纤维内发生的生化变化包括不同收缩蛋白的合成。
