Department of Physiology and Pathophysiology, College of Medicine, Xi'an Jiaotong University, Xi'an 710061, China.
Neurosci Bull. 2009 Oct;25(5):283-8. doi: 10.1007/s12264-009-0914-3.
To date, the medium and long-term space flight is urgent in need and has become a major task of our manned space flight program. There is no doubt that medium and long-term space flight has serious damaging impact upon human physiological systems. For instance, atrophy of the lower limb anti-gravity muscle can be induced during the space flight. Muscle atrophy significantly affects the flight of astronauts in space. Most importantly, it influences the precise manipulation of the astronauts and their response capacity to emergencies on returning to the atmosphere from space. Muscle atrophy caused by weightlessness may also seriously disrupt the normal life and work of the astronauts during the re-adaptation period. Here we summarize the corresponding research concentrating on weightlessness-induced changes of muscular structure and function. By combining research on muscle pain, which is a common clinical pain disease, we further provide a hypothesis concerning a dynamic feedback model of "weightlessness condition right triple arrow muscular atrophy <--> muscle pain". This may be useful to explore the neural mechanisms underlying the occurrence and development of muscular atrophy and muscle pain, through the key study of muscle spindle, and furthermore provide more effective therapy for clinical treatment.
迄今为止，中、长期空间飞行迫在眉睫，已成为我国载人航天工程的重大任务。毫无疑问，中、长期空间飞行对人体生理系统具有严重的损害影响。例如，在飞行过程中会引起下肢抗重力肌肉的萎缩。肌肉萎缩显著影响宇航员在太空中的飞行。最重要的是，它会影响宇航员对精确操作的控制以及他们对从太空返回大气层时紧急情况的反应能力。失重引起的肌肉萎缩也可能严重扰乱宇航员在重新适应期的正常生活和工作。在这里，我们总结了集中研究失重引起的肌肉结构和功能变化的相应研究。通过结合对肌肉疼痛的研究，这是一种常见的临床疼痛疾病，我们进一步提出了一个关于“失重状态右三箭头肌肉萎缩 <--> 肌肉疼痛”的动态反馈模型的假说。这可能有助于通过对肌梭的关键研究，探索肌肉萎缩和肌肉疼痛发生和发展的神经机制，并为临床治疗提供更有效的治疗方法。
