尾部悬吊对离体大鼠比目鱼肌肌梭电生理特性的影响。
Effects of tail suspension on electrophysiological characteristics of muscle spindles in isolated rat soleus muscle.
作者信息
Tang Bin, Fan Xiao-li, Wu Su-di
机构信息
Department of Physiology, Medical School of Xi'an Jiatong University, Xi'an.
出版信息
Space Med Med Eng (Beijing). 2004 Feb;17(1):1-6.
OBJECTIVE
To study changes in electrophysiological characteristics of muscle spindles induced by simulated weightlessness in isolated rats soleus.
METHOD
Weightlessness was simulated by tail-suspension in female rats. Using electro-physiological technique, the spontaneous discharge of muscle spindle and its response to ramp-and-hold stretch were observed in isolated soleus of 7 d, 14 d tail-suspended and control rats.
RESULT
Soleus muscle spindles of rat manifest a sharp decrease in spontaneous discharge frequency and the response to ramp-and-hold stretch after 7 d tail-suspension. More significant changes were observed in rats after 14 d tail-suspension.
CONCLUSION
Simulated weightlessness could induce time-related changes in electrophysiological characteristics of soleus muscle spindles in rat.
目的
研究模拟失重对离体大鼠比目鱼肌肌梭电生理特性的影响。
方法
采用尾悬吊法建立雌性大鼠失重模型。运用电生理技术，观察7天、14天尾悬吊大鼠及对照大鼠离体比目鱼肌肌梭的自发放电活动和对斜坡-保持拉伸的反应。
结果
尾悬吊7天后，大鼠比目鱼肌肌梭自发放电频率及对斜坡-保持拉伸的反应明显降低。尾悬吊14天后，变化更为显著。
结论
模拟失重可引起大鼠比目鱼肌肌梭电生理特性随时间发生改变。
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