Janerowicz Dorota, Czarnecka-Operacz Magdalena, Stawny Maciej, Silny Wojciech
Dept. of Dermatology and Allergic Diseases, University of Medical Sciences, ul. Przybyszewskiego 49, 60-355 Poznan, Poland.
Acta Dermatovenerol Alp Pannonica Adriat. 2009 Sep;18(3):131-4.
A 74-year-old patient, suffering for 20 years from polycythemia rubra vera, was treated with hydroxyurea for 2 years. Intensive xerosis (ichthyosis-like) and violaceous papules on the dorsal hand surfaces were observed. There was also reddish purple periorbital erythema resembling "heliotrope erythema". Such a disease pattern has been described as "hydroxyurea-induced dermatomyositis-like eruption" - a drug-adverse reaction associated with hydroxyurea therapy. The reaction has typical dermal features of dermatomyositis without any systemic symptoms (in the case of our patient, antinuclear antibodies absent and creatine phosphokinase within the normal range). The above reaction is associated with chronic hydroxyurea uptake and, after withdrawing the drug, alleviation of skin lesions usually takes place after 10 days to 18 months with no recurrences. In the case of our patient, we observed clinical improvement after 3 months; xerosis decreased, heliotrope erythema vanished, and there was also a decrease in both the number and intensity of violaceous papules on the dorsal hand surfaces.
一名74岁的患者，患真性红细胞增多症20年，接受羟基脲治疗2年。观察到双手背出现严重的皮肤干燥（鱼鳞病样）和紫色丘疹。还存在类似“向阳疹”的紫红色眶周红斑。这种疾病模式被描述为“羟基脲诱导的皮肌炎样皮疹”——一种与羟基脲治疗相关的药物不良反应。该反应具有皮肌炎典型的皮肤特征，但无任何全身症状（就我们的患者而言，抗核抗体阴性，肌酸磷酸激酶在正常范围内）。上述反应与长期服用羟基脲有关，停药后，皮肤病变通常在10天至18个月内缓解，且无复发。就我们的患者而言，3个月后观察到临床改善；皮肤干燥减轻，向阳疹消失，双手背紫色丘疹的数量和严重程度也有所减少。
