来自小花山柰的5,7-二甲氧基黄酮的氨基和硝基衍生物及其对KB细胞系的细胞毒性。
Amino and nitro derivatives of 5,7-dimethoxyflavone from Kaempferia parviflora and cytotoxicity against KB cell line.
作者信息
Wanich Suchana, Yenjai Chavi
机构信息
Natural Products Research Unit, Center for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
出版信息
Arch Pharm Res. 2009 Sep;32(9):1185-9. doi: 10.1007/s12272-009-1901-y. Epub 2009 Sep 26.
Structural modification of 5,7-dimethoxyflavone isolated from Kaempferia parviflora furnished two nitro and seven amino derivatives. Among these, six new (3, 5-6, 8-10) and three known (2, 4, 7) flavonoid derivatives were synthesized. All compounds were evaluated for cytotoxicity against KB cell line using colorimetric method. Compounds 6 and 8 exhibited strong cytotoxicity with IC50 values of 6.80 and 5.84 microg/mL, respectively.
从小花山柰中分离得到的5,7-二甲氧基黄酮进行结构修饰，得到了两种硝基衍生物和七种氨基衍生物。其中，合成了六种新的（3, 5 - 6, 8 - 10）黄酮类衍生物和三种已知的（2, 4, 7）黄酮类衍生物。采用比色法对所有化合物针对KB细胞系的细胞毒性进行了评估。化合物6和8表现出较强的细胞毒性，IC50值分别为6.80和5.84微克/毫升。
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