Yenjai Chavi, Wanich Suchana, Pitchuanchom Siripit, Sripanidkulchai Bungon
Natural Products Research Unit, Center for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
Arch Pharm Res. 2009 Sep;32(9):1179-84. doi: 10.1007/s12272-009-1900-z. Epub 2009 Sep 26.
5,7-Dimethoxyflavone, a major compound from Kaempferia parviflora, was used as a starting material for structural modification. Seven flavonoid derivatives have been synthesized from this flavone. Two new oxime derivatives 4 and 6 exhibited cytotoxicity against HepG2 cell line with IC50 values of 36.38 and 25.34 microg/mL, respectively, and against T47D cell line with IC50 values of 41.66 and 22.94 microg/mL, respectively. Compound 7 showed cytotoxicity against HepG2 and T47D cell lines with IC50 values of 21.36 and 25.00 microg/mL, respectively. Compounds 6 and 7 showed cytotoxicity nearly equal to the tamoxifen standard. In addition, oxime 6 exhibited antifungal activity against Candida albicans with an IC50 value of 48.98 microg/mL.
5,7-二甲氧基黄酮是少花山姜的一种主要化合物，用作结构修饰的起始原料。已从该黄酮合成了七种黄酮衍生物。两种新的肟衍生物4和6对HepG2细胞系表现出细胞毒性，IC50值分别为36.38和25.34微克/毫升，对T47D细胞系的IC50值分别为41.66和22.94微克/毫升。化合物7对HepG2和T47D细胞系表现出细胞毒性，IC50值分别为21.36和25.00微克/毫升。化合物6和7的细胞毒性几乎与他莫昔芬标准相当。此外，肟6对白色念珠菌表现出抗真菌活性，IC50值为48.98微克/毫升。
