胆固醇酯转运蛋白基因多态性与冠状动脉疾病的关联：一项荟萃分析。

Association of the polymorphisms of the cholesteryl ester transfer protein gene with coronary artery disease: a meta-analysis.

作者信息

Zhang Ruizhe, Xie Qingya, Xiao Pingxi

机构信息

Department of Cardiology, Sir Run Run, Hospital, Nanjing Medical University, Nanjing, China.

Department of Cardiology, The Forth Affiliated Hospital, Nanjing Medical University, Nanjing, China.

出版信息

Front Cardiovasc Med. 2023 Dec 7;10:1260679. doi: 10.3389/fcvm.2023.1260679. eCollection 2023.

DOI:10.3389/fcvm.2023.1260679

PMID:38146445

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10749314/

Abstract

AIMS

This meta-analysis aimed to assess the association of the polymorphisms of cholesterol ester transfer protein () rs708272 (G>A), rs5882 (G>A), rs1800775 (C>A), rs4783961 (G>A), rs247616 (C>T), rs5883 (C>T), rs1800776 (C>A), and rs1532624 (C>A) with coronary artery disease (CAD) and the related underlying mechanisms.

METHODS

A comprehensive search was performed using five databases such as PubMed, EMBASE, Web of Science, Cochrane Library and Scopus to obtain the appropriate articles. The quality of the included studies was assessed by the Newcastle-Ottawa Scale. The statistical analysis of the data was performed using STATA 17.0 software. The association between gene polymorphisms and risk of CAD was estimated using the pooled odds ratio (OR) and 95% confidence interval (95% CI). The association of gene polymorphisms with lipids and with CETP levels was assessed using the pooled standardized mean difference and corresponding 95% CI. < 0.05 was considered statistically significant.

RESULTS

A total of 70 case-control studies with 30,619 cases and 31,836 controls from 46 articles were included. The results showed the rs708272 polymorphism was significantly associated with a reduced risk of CAD under the allele model (OR=0.846, < 0.001), the dominant model (OR=0.838, < 0.001) and the recessive model (OR=0.758, < 0.001). AA genotype and GA genotype corresponded to higher high-density lipoprotein cholesterol (HDL-C) concentrations in the blood compared with GG genotype across the studied groups (all < 0.05). The rs5882 and rs1800775 polymorphisms were not significantly associated with CAD under the allele model ( = 0.802, = 0.392), the dominant model ( = 0.556, = 0.183) and the recessive model ( = 0.429, = 0.551). Similarly, the other mentioned gene polymorphisms were not significantly associated with CAD under the three genetic models.

CONCLUSIONS

The rs708272 polymorphism shows a significant association with CAD, and the carriers of the allele A are associated with a lower risk of CAD and higher HDL-C concentrations in the blood compared to the non-carriers. The rs5882, rs1800775, rs4783961, rs247616, rs5883, rs1800776, and rs1532624 are not significantly associated with CAD.

SYSTEMATIC REVIEW REGISTRATION

https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023432865, identifier: CRD42023432865.

摘要

目的

本荟萃分析旨在评估胆固醇酯转运蛋白（CETP）基因rs708272（G>A）、rs5882（G>A）、rs1800775（C>A）、rs4783961（G>A）、rs247616（C>T）、rs5883（C>T）、rs1800776（C>A）和rs1532624（C>A）多态性与冠状动脉疾病（CAD）的关联及其相关潜在机制。

方法

使用PubMed、EMBASE、Web of Science、Cochrane图书馆和Scopus等五个数据库进行全面检索以获取合适的文章。纳入研究的质量通过纽卡斯尔-渥太华量表进行评估。使用STATA 17.0软件进行数据的统计分析。使用合并比值比（OR）和95%置信区间（95%CI）估计CETP基因多态性与CAD风险之间的关联。使用合并标准化均值差和相应的95%CI评估CETP基因多态性与血脂及CETP水平之间的关联。P<0.05被认为具有统计学意义。

结果

共纳入46篇文章中的70项病例对照研究，包括30619例病例和31836例对照。结果显示，在等位基因模型（OR=0.846，P<0.001）、显性模型（OR=0.838，P<0.001）和隐性模型（OR=0.758，P<0.001）下，CETP基因rs708272多态性与CAD风险降低显著相关。在所有研究组中，与GG基因型相比，AA基因型和GA基因型对应的血液中高密度脂蛋白胆固醇（HDL-C）浓度更高（均P<0.05）。在等位基因模型（P=0.802，P=0.392）、显性模型（P=0.556，P=0.183）和隐性模型（P=0.429，P=0.551）下，CETP基因rs5882和rs1800775多态性与CAD无显著关联。同样，在三种遗传模型下，其他提及的基因多态性与CAD均无显著关联。