Mathieu M G, Miles A K, Li G, McArdle S E B, Rees R C
The John van Geest Cancer Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, UK.
J BUON. 2009 Sep;14 Suppl 1:S97-102.
Since van der Bruggen and colleagues first identified specific human tumour-associated antigens of the MAGE family, numerous potential immunotherapeutic targets have been discovered, often belonging to the so-called cancer/ testis gene family. Several members of this group have been described as immunogenic and have been utilised in clinical trials. In a search for interesting targets within this family, our laboratory has focussed its works for a number of years on two novel cancer/testis antigens called T21 and HAGE. In this article, we will focus our discussion on their levels of expression in a wide variety of both normal and cancer tissues, their possible role in tumour cell development and proliferation, and their immunogenic potential.
自从范德布鲁根及其同事首次鉴定出MAGE家族的特定人类肿瘤相关抗原以来，已经发现了许多潜在的免疫治疗靶点，这些靶点通常属于所谓的癌/睾丸基因家族。该家族的几个成员已被描述为具有免疫原性，并已用于临床试验。为了在这个家族中寻找有趣的靶点，我们实验室多年来一直将工作重点放在两种名为T21和HAGE的新型癌/睾丸抗原上。在本文中，我们将重点讨论它们在多种正常组织和癌组织中的表达水平、它们在肿瘤细胞发育和增殖中的可能作用以及它们的免疫原性潜力。
