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Cancers (Basel). 2011 Jun 9;3(2):2554-96. doi: 10.3390/cancers3022554.
Our knowledge of tumor immunology has resulted in multiple approaches for the treatment of cancer. However, a gap between research of new tumors markers and development of immunotherapy has been established and very few markers exist that can be used for treatment. The challenge is now to discover new targets for active and passive immunotherapy. This review aims at describing recent advances in biomarkers and tumor antigen discovery in terms of antigen nature and localization, and is highlighting the most recent approaches used for their discovery including "omics" technology.
我们对肿瘤免疫学的认识已经产生了多种治疗癌症的方法。然而,新的肿瘤标志物的研究与免疫疗法的发展之间存在差距,并且几乎没有可以用于治疗的标志物。现在的挑战是发现主动和被动免疫疗法的新靶点。本文旨在描述在抗原性质和定位方面,生物标志物和肿瘤抗原发现的最新进展,并强调用于发现它们的最新方法,包括“组学”技术。