Grieve R B
Dept. of Pathology, Colorado State University, Fort Collins 80523.
Acta Trop. 1990 Jul;47(5-6):399-402. doi: 10.1016/0001-706x(90)90041-w.
Investigations of the immunobiology of tissue stages of larval nematodes reveal several common, immunologically relevant features associated with the cuticle and epicuticle. First, commonality exists between surface and excretory-secretory antigens. Second, larval surfaces are often directly involved in evasion of host immune responses. Third, antigens present on the parasite surface can be involved in immunopathology, either directly through tissue damage or via systemic immunomodulatory events. Finally, in some instances, correlations can be inferred between immune protection and surface antigens. These concepts are illustrated through research on larval Dirofilaria immitis and Toxocara canis.
对幼虫期线虫组织阶段免疫生物学的研究揭示了与角质层和表皮相关的几个常见的、与免疫相关的特征。首先，表面抗原与排泄-分泌抗原存在共性。其次，幼虫表面通常直接参与逃避宿主免疫反应。第三，寄生虫表面存在的抗原可直接通过组织损伤或通过全身性免疫调节事件参与免疫病理学过程。最后，在某些情况下，可以推断出免疫保护与表面抗原之间的相关性。通过对犬恶丝虫幼虫和犬弓首蛔虫的研究阐述了这些概念。
