健康 8 岁儿童的脂肪和葡萄糖代谢特征因性别而异。

Metabolic profiles of fat and glucose differ by gender in healthy 8-year-olds.

机构信息

Department of Pediatrics, Institute of Clinical Sciences, The Sahlgrenska Academy, Göteborg University, Göteborg, Sweden.

出版信息

Acta Paediatr. 2010 Jan;99(1):78-82. doi: 10.1111/j.1651-2227.2009.01513.x.

DOI:10.1111/j.1651-2227.2009.01513.x

PMID:19785634

Abstract

OBJECTIVE

The aim was to investigate if metabolic markers were associated with anthropometry and weight increase in healthy 8-year-olds.

METHODS

Ninety-seven healthy children, 66 of whom had been examined at the age of 4 years, were investigated. Dual energy X-ray absorptiometry was performed to determine fat (FM) and lean body mass (LBM). Plasma glucose and serum levels of insulin, cholesterol, triglycerides, adiponectin and leptin were analysed and HOMA-indices were calculated.

RESULTS

Despite similar anthropometry, metabolic markers differed by gender. Sixteen % of the children were overweight or obese. Body mass index (BMI) was strongly correlated to FM. Anthropometric measures except LBM correlated to metabolic markers in the girls. Boys had higher concentrations of plasma glucose than girls. In overweight children, insulin was negatively associated with LBM. Leptin and the ratio between leptin and adiponectin, but not adiponectin, were significantly associated with HOMA-IR and body composition.

CONCLUSION

The metabolic profile of plasma glucose, serum leptin, fasting insulin and related HOMA indices differed by gender, despite no difference in BMI or FM. LBM, but not FM correlated to the insulin concentration in the overweight children. Leptin was the best marker of overweight.

摘要

目的

研究代谢标志物是否与健康 8 岁儿童的人体测量学和体重增加有关。

方法

对 97 名健康儿童进行了研究，其中 66 名儿童在 4 岁时接受了检查。采用双能 X 射线吸收法测定脂肪（FM）和瘦体重（LBM）。分析血浆葡萄糖和血清胰岛素、胆固醇、甘油三酯、脂联素和瘦素水平，并计算 HOMA 指数。

结果

尽管人体测量学相似，但代谢标志物存在性别差异。16%的儿童超重或肥胖。体重指数（BMI）与 FM 密切相关。除 LBM 外，女性的人体测量学指标与代谢标志物相关。男孩的血浆葡萄糖浓度高于女孩。在超重儿童中，胰岛素与 LBM 呈负相关。瘦素和瘦素与脂联素的比值，而不是脂联素，与 HOMA-IR 和身体成分显著相关。