在非糖尿病青少年中，血浆瘦素与胰岛素抵抗相关，且独立于年龄、体重指数、脂肪量、血脂及青春期发育。

Plasma leptin is associated with insulin resistance independent of age, body mass index, fat mass, lipids, and pubertal development in nondiabetic adolescents.

作者信息

Huang K-C, Lin R C Y, Kormas N, Lee L-T, Chen C-Y, Gill T P, Caterson I D

机构信息

Department of Family Medicine, National Taiwan University Hospital, Taiwan.

出版信息

Int J Obes Relat Metab Disord. 2004 Apr;28(4):470-5. doi: 10.1038/sj.ijo.0802531.

DOI:10.1038/sj.ijo.0802531

PMID:14993909

Abstract

OBJECTIVE

The rising epidemic worldwide in overweight and obese children requires urgent attention. Leptin has been found to be associated with body weight control and possibly affects insulin sensitivity. Since insulin resistance is associated with obesity in adults and possibly in adolescents, we set out to investigate the association of plasma leptin level with various anthropometric indices, body fat mass (FM), lipids, and insulin resistance (IR) index in nondiabetic adolescents.

DESIGN

A cross-sectional study from three high schools in Taipei City in Taiwan.

SUBJECTS

A total of 402 nondiabetic subjects (162 boys and 240 girls; age range, 10-19 y; mean age, 15.8+/-1.9 y, and mean body mass index (BMI), 24.8+/-4.6 kg/m(2)) were recruited.

MEASUREMENTS

The fasting plasma leptin, plasma glucose, insulin, lipids, and anthropometric indices including height, weight, waist (WC) and hip circumferences, and waist-to-hip ratio (WHR) were examined. Total body FM and percentage body fat (FM%) were obtained from dual-energy X-ray absorptiometry. The homeostasis model was applied to estimate the degree of IR.

RESULTS

The plasma leptin levels were significantly higher in girls (17.45+/-10.13 ng/ml) than boys (8.81+/-6.71 ng/ml, P<0.001). The plasma leptin levels were positively correlated to BMI, WC, WHR, FM, FM%, and triglycerides (TG). The IR index was positively correlated to BMI, WC, WHR, FM, FM%, TG, and leptin. Using the multivariate linear regression models, we found that plasma leptin remains significantly associated with IR index even after adjusting for age, gender, BMI, FM, WC, Tanner stage, and TG.

CONCLUSION

Plasma leptin was associated with IR index independent of age, gender, BMI, FM, WC, Tanner stage, and TG. Plasma leptin levels in adolescents could be a predictor for the development of the metabolic syndrome disorders and cardiovascular diseases.

摘要

目的

全球超重和肥胖儿童的流行趋势不断上升，这一情况亟待关注。已发现瘦素与体重控制有关，并且可能影响胰岛素敏感性。由于胰岛素抵抗在成年人中与肥胖相关，在青少年中可能也如此，因此我们着手研究非糖尿病青少年血浆瘦素水平与各种人体测量指标、体脂肪量（FM）、血脂及胰岛素抵抗（IR）指数之间的关联。

设计

一项来自台湾台北市三所高中的横断面研究。

研究对象

共招募了402名非糖尿病受试者（162名男孩和240名女孩；年龄范围10 - 19岁；平均年龄15.8±1.9岁，平均体重指数（BMI）24.8±4.6kg/m²）。

测量指标

检测空腹血浆瘦素、血糖、胰岛素、血脂以及包括身高、体重、腰围（WC）、臀围和腰臀比（WHR）在内的人体测量指标。通过双能X线吸收法获取全身FM和体脂肪百分比（FM%）。应用稳态模型评估IR程度。

结果

女孩的血浆瘦素水平（17.45±10.13ng/ml）显著高于男孩（8.81±6.71ng/ml，P<0.001）。血浆瘦素水平与BMI、WC、WHR、FM、FM%及甘油三酯（TG）呈正相关。IR指数与BMI、WC、WHR、FM、FM%、TG及瘦素呈正相关。使用多元线性回归模型，我们发现即使在调整年龄、性别、BMI、FM、WC、坦纳分期和TG后，血浆瘦素仍与IR指数显著相关。