Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Marqués de Valdecilla University Hospital (University of Cantabria), Santander, Spain.
Acta Neurol Scand. 2010 Feb;121(2):136-8. doi: 10.1111/j.1600-0404.2009.01261.x. Epub 2009 Sep 24.
Oxidative stress is implicated in Parkinson's disease (PD) and Alzheimer's disease (AD), and heme oxygenase-1 (HO-1) is a potent antioxidant overexpressed in PD substantia nigra and AD cerebral cortex and hippocampus, indicating a possible up-regulation of antioxidant defenses in both neurodegenerative diseases. The role of HO-1 in peripheral blood of PD and AD patients remains unresolved.
We measured serum HO-1 levels in 107 patients with PD, 105 patients with AD, 104 controls for PD and 120 controls for AD.
The median serum concentration of HO-1 was significantly higher in PD patients (2.04 ng/ml) compared with that of PD controls (1.69 ng/ml, P = 0.016), with PD patients predominating over controls in the upper tertile of serum HO-1 levels, whereas there was more PD controls than PD patients in the lower tertile (P = 0.006). Median serum levels of HO-1 did not differ significantly between AD patients and AD controls.
The increase of serum HO-1 levels in PD patients could indicate a systemic antioxidant reaction related to a chronic oxidative stress state in PD brain.
氧化应激与帕金森病（PD）和阿尔茨海默病（AD）有关，血红素加氧酶-1（HO-1）在 PD 黑质和 AD 大脑皮层和海马中过度表达，是一种有效的抗氧化剂，这表明在这两种神经退行性疾病中可能存在抗氧化防御的上调。HO-1 在 PD 和 AD 患者外周血中的作用仍未解决。
我们测量了 107 名 PD 患者、105 名 AD 患者、104 名 PD 对照组和 120 名 AD 对照组的血清 HO-1 水平。
PD 患者的血清 HO-1 中位数浓度（2.04ng/ml）明显高于 PD 对照组（1.69ng/ml，P=0.016），血清 HO-1 水平较高的 PD 患者在前三分位中占优势，而血清 HO-1 水平较低的 PD 对照组则多于 PD 患者（P=0.006）。AD 患者和 AD 对照组的血清 HO-1 水平中位数无显著差异。
PD 患者血清 HO-1 水平升高可能表明与 PD 大脑慢性氧化应激状态有关的全身抗氧化反应。
