Hofstee Herman M A, Voskuyl Alexandre E, Serné Erik H, Smulders Yvo M
VU Medisch Centrum, Afd. Interne Geneeskunde, Amsterdam, The Netherlands.
Ned Tijdschr Geneeskd. 2009;153:B216.
Primary Raynaud's phenomenon (RP) is a relatively common disorder. Most patients with primary RP have only mild symptoms and do not develop complications. Distinguishing primary from secondary RP is important with respect to complications, and for prognosis and treatment. Secondary RP mainly manifests as part of systemic connective tissue disease. About 13% of patients diagnosed initially as having primary RP develop a systemic disorder within the following few years. Both auto-immune serology including antinuclear antibodies (ANA), and capillaroscopy are important diagnostic tools if one suspects the existence or development of a systemic disorder. Calcium antagonists are the cornerstone of RP pharmacotherapy.
原发性雷诺现象（RP）是一种相对常见的疾病。大多数原发性RP患者仅有轻微症状，不会出现并发症。区分原发性和继发性RP对于并发症、预后及治疗都很重要。继发性RP主要表现为系统性结缔组织病的一部分。最初被诊断为原发性RP的患者中，约13%在接下来的几年内会发展为系统性疾病。如果怀疑存在或发展为系统性疾病，自身免疫血清学检查（包括抗核抗体[ANA]）和毛细血管镜检查都是重要的诊断工具。钙拮抗剂是RP药物治疗的基石。
