简易精神状态检查对阿尔茨海默病患者的脑萎缩很敏感。
Mini-mental state examination is sensitive to brain atrophy in Alzheimer's disease.
机构信息
Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Oslo, Norway.
出版信息
Dement Geriatr Cogn Disord. 2009;28(3):252-8. doi: 10.1159/000241878. Epub 2009 Sep 25.
BACKGROUND/AIMS: Screening instruments such as the Mini-Mental State Examination (MMSE) are useful for the early identification of Alzheimer's disease (AD). We tested whether macrostructural differences in brain volume are related to the MMSE.
METHODS
The MMSE was related to cortical thickness and the volume of 19 brain structures in 96 patients with mild to moderate AD. In addition, the patients were compared to 93 healthy elderly controls.
RESULTS
The MMSE was related to the volume of the total brain, cerebral cortex, accumbens, cerebral white matter, inferior lateral ventricles and hippocampus. Positive correlations with cortical thickness were found for 41% of the brain surface, and 58% of this area was significantly thinner in AD.
CONCLUSION
The MMSE is sensitive to macrostructural brain atrophy in AD, but also to morphometric variation not specifically related to AD.
背景/目的：筛查工具，如简易精神状态检查（MMSE），有助于早期发现阿尔茨海默病（AD）。我们测试了脑容量的宏观结构差异是否与 MMSE 相关。
方法
将 MMSE 与 96 名轻度至中度 AD 患者的皮质厚度和 19 个脑结构的体积相关联。此外，将患者与 93 名健康老年对照组进行比较。
结果
MMSE 与全脑、大脑皮层、伏隔核、脑白质、侧脑室下角和海马体的体积相关。大脑表面有 41%与皮质厚度呈正相关，AD 患者中 58%的这部分区域明显变薄。
结论
MMSE 对 AD 中的宏观脑萎缩敏感，但也对与 AD 不特异相关的形态计量学变化敏感。
Zotero 插件