SOD Genetica delle Malattie Neurodegenerative e Metaboliche, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italia.
Eur Neurol. 2009;62(6):356-61. doi: 10.1159/000242010. Epub 2009 Sep 26.
In recent years, the involvement of the immune system in acquired forms of cerebellar ataxia has been frequently demonstrated. In this study, we describe 6 out of 49 patients with subacute or chronic progressive cerebellar ataxia in whom antibodies against neuronal and non-neuronal antigens were identified. Two women had anti-Yo antibodies; two patients had anti-gliadin antibodies in the presence of celiac disease; one patient had a complex autoimmune disorder associated with anti-Ro-52/SS-A and anti-muscle-specific kinase antibodies, and a patient developed subacute cerebellar syndrome associated with the presence of a prostatic adenocarcinoma and atypical antibodies reacting both with cerebellar tissue and with the prostatic tumor. Our study confirms previous findings in paraneoplastic syndromes, and indicates that at least 10% of sporadic cerebellar ataxia may be related to immune-mediated mechanisms.
近年来，免疫系统在获得性小脑共济失调中的作用已被频繁证实。在这项研究中，我们描述了 49 例亚急性或慢性进行性小脑共济失调患者中的 6 例，这些患者的神经元和非神经元抗原抗体被识别。两名女性患者存在抗 Yo 抗体；两名患者在患有乳糜泻的情况下存在抗麦胶蛋白抗体；一名患者患有与抗 Ro-52/SS-A 和抗肌肉特异性激酶抗体相关的复杂自身免疫性疾病，一名患者发生与前列腺腺癌和非典型抗体相关的亚急性小脑综合征，这些抗体既与小脑组织反应，也与前列腺肿瘤反应。我们的研究证实了副肿瘤综合征中的先前发现，并表明至少 10%的散发性小脑共济失调可能与免疫介导的机制有关。
