Department of Dermatology, Health Sciences Faculty, University of Copenhagen, Roskilde Hospital, Roskilde, Denmark.
Skin Pharmacol Physiol. 2009;22(6):295-8. doi: 10.1159/000241298. Epub 2009 Sep 25.
A simple ex vivo screening technique would be of interest for mass screening of substances for potential barrier disruptive qualities. Ex vivo water absorption as a marker of skin barrier integrity was studied on pig ear skin. Skin water absorption was quantified by weighing and weight changes were found to reflect prehydration barrier damage. It is suggested that this simple model may be elaborated to provide a rapid, economical screening tool for potential skin irritants.
对于潜在的破坏屏障物质的大规模筛选，一种简单的离体筛选技术将是很有意义的。本文以猪耳皮肤为模型，研究了体外水分吸收作为皮肤屏障完整性的标志物。通过称重来量化皮肤水分吸收，发现重量变化反映了预水合屏障损伤。有人建议，这种简单的模型可以进一步完善，为潜在的皮肤刺激性物质提供一种快速、经济的筛选工具。
