El-Sayed Mahmoud S, Ali Nagia, Al-Bayatti Mudhaffar
Department of Mathematical Sciences, Liverpool University, Liverpool, England, UK.
Blood Coagul Fibrinolysis. 2009 Dec;20(8):679-85. doi: 10.1097/MBC.0b013e3283316196.
This cross-sectional study aimed to explore the relationship between aerobic power and the main determinants of blood rheology namely plasma viscosity, plasma fibrinogen concentration and haematocrit. Ninety-three normal healthy individuals (VO2max 48.3 ml/kg per min), who were familiarized with the laboratory environment and testing procedures, participated in the study. Aerobic power as assessed by maximal oxygen consumption (VO2max) was determined by using an incremental exercise protocol on either a treadmill or a stationary bike. Oxygen consumption was measured online using a computer-based metabolic system. In a standardized resting condition, venous blood samples were removed from a prominent vein of the nondominant arm. Aliquots of whole blood were measured for haematocrit (in triplicate), whereas plasma was assayed for fibrinogen concentration and viscosity (in duplicate) using semiautomatic coagulometer and capillary viscometer; respectively. The mean values for haematocrit (41.9 +/- 2.5%), plasma viscosity (1.56 +/- 0.27 mPa s) and plasma fibrinogen (272.1 +/- 86.9 mg/dl) were within the normal range for normal participants. Pearson correlation coefficients and regression analysis were used for statistical evaluations. In this population, VO2max negatively correlated with plasma viscosity (P < 0.01) and plasma fibrinogen concentration (P < 0.01). Although VO2max positively correlated with haematocrit, this correlation was not as strong. Thus, high aerobic power as assessed by maximal oxygen consumption appears to be associated with lower plasma viscosity and lower plasma fibrinogen. The significant negative relationships between VO2max and plasma viscosity and plasma fibrinogen might suggest that blood is more dilute in individuals with high aerobic power. This could probably be due to an expansion of plasma volume, which is commonly seen in those who are physically active and exhibit a higher level of cardiorespiratory fitness.
这项横断面研究旨在探讨有氧能力与血液流变学的主要决定因素之间的关系，这些决定因素即血浆粘度、血浆纤维蛋白原浓度和血细胞比容。93名正常健康个体（最大摄氧量为48.3毫升/千克每分钟）参与了该研究，他们对实验室环境和测试程序很熟悉。通过递增运动方案，在跑步机或固定自行车上测定以最大摄氧量（VO2max）评估的有氧能力。使用基于计算机的代谢系统在线测量耗氧量。在标准化的静息状态下，从非优势手臂的一条明显静脉采集静脉血样。对全血等分试样测量血细胞比容（一式三份），而使用半自动凝血仪和毛细管粘度计分别对血浆测定纤维蛋白原浓度和粘度（一式两份）。血细胞比容（41.9±2.5%）、血浆粘度（1.56±0.27毫帕秒）和血浆纤维蛋白原（272.1±86.9毫克/分升）的平均值在正常参与者的正常范围内。使用Pearson相关系数和回归分析进行统计评估。在该人群中，VO2max与血浆粘度（P<0.01）和血浆纤维蛋白原浓度（P<0.01）呈负相关。尽管VO2max与血细胞比容呈正相关，但这种相关性不强。因此，以最大摄氧量评估的高有氧能力似乎与较低的血浆粘度和较低的血浆纤维蛋白原有关。VO2max与血浆粘度和血浆纤维蛋白原之间的显著负相关可能表明，有氧能力高的个体血液更稀释。这可能是由于血浆量增加，这在身体活跃且心肺适能水平较高的人群中很常见。
