Antoch G, Herrmann K, Heusner T A, Buck A K
Institut für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstrasse 55, Essen, Germany.
Radiologe. 2009 Dec;49(12):1109-16. doi: 10.1007/s00117-009-1852-9.
Morphological and functional imaging methods are used for staging of gastrointestinal stromal tumors (GIST) and to follow-up GIST patients undergoing therapy. Computed tomography is the most frequently used morphological imaging procedure and has been recommended as the imaging method of choice according to current GIST guidelines. However, positron emission tomography using [(18)F]-2-fluoro-2-deoxy-D-glucose (FDG-PET) as the radiotracer has shown to be advantageous over morphological imaging procedures when assessing therapy response at an early time point. While tumor size reduction in morphological imaging typically requires time to develop, a decrease in FDG uptake can be detected as early as 24 h following therapy initiation. To overcome the limitations of size-based therapy response assessment on morphological imaging procedures, new density-based therapy response criteria have been developed and implemented for GIST. This review addresses both indications and accuracy of morphological and functional imaging modalities for GIST.
形态学和功能成像方法用于胃肠道间质瘤(GIST)的分期以及对接受治疗的GIST患者进行随访。计算机断层扫描是最常用的形态学成像检查方法,根据当前GIST指南,它已被推荐为首选的成像方法。然而,以[(18)F]-2-氟-2-脱氧-D-葡萄糖(FDG-PET)作为放射性示踪剂的正电子发射断层扫描在早期评估治疗反应时已显示出优于形态学成像检查方法。虽然形态学成像中肿瘤大小的缩小通常需要时间来显现,但在治疗开始后24小时就可以检测到FDG摄取的减少。为了克服基于大小的治疗反应评估在形态学成像检查方法上的局限性,已针对GIST制定并实施了新的基于密度的治疗反应标准。本综述阐述了GIST形态学和功能成像方式的适应证及准确性。