[透明质酸及其在诊断与治疗中的重要性]

[Hyaluronan and the importance of hyaluronan in diagnosis and treatment].

作者信息

Aytekin Metin, Caylak Emrah

机构信息

Cleveland Clinic, Department of Pathobiology, Cleveland, Ohio, USA.

出版信息

Tuberk Toraks. 2009;57(3):356-64.

PMID:19787478

Abstract

Hyaluronan is a glycosylaminoglycan and is the main component of the extracellular matrix. It was first described in 1934 and has many structural and physiological functions in the human body. An upcoming area of study relates to the hyaluronan receptors, since these affect the metabolism and function of hyaluronan. This knowledge will be useful in evaluating the role of hyaluronan in diseases, as a therapeutic agent for inflammation disorders and as a diagnostic biomarker. In this review, we discussed the structure of hyaluronan and its role in diseases.

摘要

透明质酸是一种糖胺聚糖，是细胞外基质的主要成分。它于1934年首次被描述，在人体中具有多种结构和生理功能。一个即将兴起的研究领域与透明质酸受体有关，因为这些受体影响透明质酸的代谢和功能。这些知识将有助于评估透明质酸在疾病中的作用，作为炎症性疾病的治疗剂以及作为诊断生物标志物。在这篇综述中，我们讨论了透明质酸的结构及其在疾病中的作用。