Anderegg Ulf, Simon Jan C, Averbeck Marco
Department of Dermatology, Venerology and Allergology, University of Leipzig, Leipzig, Germany.
Exp Dermatol. 2014 May;23(5):295-303. doi: 10.1111/exd.12370.
In recent years, hyaluronan (HA) has become an increasingly attractive substance as a non-immunogenic filler and scaffolding material in cosmetic dermatology. Despite its wide use for skin augmentation and rejuvenation, relatively little is known about the molecular structures and interacting proteins of HA in normal and diseased skin. However, a comprehensive understanding of cutaneous HA homeostasis is required for future the development of HA-based applications for skin regeneration. This review provides an update on HA-based structures, expression, metabolism and its regulation, function and pharmacological targeting of HA in skin.
近年来，透明质酸（HA）作为一种非免疫原性填充剂和支架材料，在美容皮肤科领域已成为一种越来越有吸引力的物质。尽管它广泛用于皮肤填充和年轻化，但对于正常皮肤和患病皮肤中HA的分子结构及相互作用蛋白却知之甚少。然而，为了未来基于HA的皮肤再生应用的发展，需要全面了解皮肤HA的稳态。本文综述了皮肤中基于HA的结构、表达、代谢及其调控、功能和药物靶向等方面的最新进展。
