University of Birmingham, Birmingham, United Kingdom.
Semin Thromb Hemost. 2009 Sep;35(6):543-7. doi: 10.1055/s-0029-1240014. Epub 2009 Sep 28.
Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with a high risk of embolic stroke (cause in 15% of all strokes and 30% of strokes in those >75 years of age). Anticoagulation with warfarin will reduce stroke risk by about two thirds. The main risks of anticoagulation, namely bleeding, can be minimized by maintaining anticoagulation control within the international normalized range range of 2.0 to 3.0 (target: 2.5). To have a public health impact, patients with AF need efficient and correct identification, with appropriate treatment directed at those patients at most risk from the condition.
心房颤动（AF）是最常见的心律失常，与栓塞性中风（所有中风的 15%和 75 岁以上中风的 30%）的风险较高有关。华法林抗凝可将中风风险降低约三分之二。抗凝的主要风险，即出血，可以通过将抗凝控制维持在国际标准化比值 2.0 至 3.0 的范围内（目标：2.5）来最小化。为了产生公共卫生影响，需要有效地识别出 AF 患者，并对处于最高风险的患者进行适当的治疗。
