State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, the Chinese Academy of Sciences, Kunming, People's Republic of China.
Planta Med. 2010 Mar;76(4):353-7. doi: 10.1055/s-0029-1186168. Epub 2009 Sep 28.
Four serratane-type triterpenes ( 1- 4) were isolated from D. COMPLANATUM. Their chemical structures were elucidated as 14alpha,15alpha,20beta,21beta,24,27alpha,29-heptahydroxyserrat-3-one ( 1), 3beta,14alpha,15alpha,20beta,21beta,24,27alpha,29-octahydroxyserratane ( 2), 3alpha,14alpha,20beta,21beta,24,27alpha,29-heptahydroxyserratane ( 3) and 3beta,14alpha,21beta,24,27alpha-pentahydroxyl-serratane-29-yl ( E)- P-coumarate ( 4) by spectroscopic methods (MS, 1D and 2D NMR) and X-ray crystallography. Interestingly, the most characteristic methylene (C-27) of the serratane ring C was oxidized to a methine. Compound 4 showed significant cytotoxic activity against the human leukemia K562/S and the doxorubicin-resistant K562/R cell lines, but the other compounds were inactive.
从 D. COMPLANATUM 中分离得到 4 种serratane 型三萜（1-4）。通过光谱方法（MS、1D 和 2D NMR）和 X 射线晶体学解析，它们的化学结构被阐明为 14α,15α,20β,21β,24,27α,29-七羟基serrat-3-one（1）、3β,14α,15α,20β,21β,24,27α,29-八羟基serratane（2）、3α,14α,20β,21β,24,27α,29-七羟基serratane（3）和 3β,14α,21β,24,27α-五羟基serratane-29-yl（E）-对香豆酸酯（4）。有趣的是，serratane 环 C 的最特征亚甲基（C-27）被氧化为亚甲基。化合物 4 对人白血病 K562/S 和阿霉素耐药 K562/R 细胞系表现出显著的细胞毒性活性，但其他化合物则没有活性。
