Straus Farber Rebecca, Devilliers Laetitia, Miller Aaron, Lublin Fred, Law Meng, Fatterpekar Girish, Delman Bradley, Naidich Thomas
Mount Sinai Medical Center, Department of Neurology, New York, NY 10029, USA.
J Magn Reson Imaging. 2009 Oct;30(4):732-6. doi: 10.1002/jmri.21922.
To compare diffusion weighted imaging metrics in gray and white matter brain regions of patients diagnosed with multiple sclerosis (MS) to those diagnosed with secondary demyelinating diseases such as neurosarcoid and acute disseminated encephalomyelitis (ADEM).
Diffusion weighted scans were performed and apparent diffusion coefficients of 12 regions of interest were determined in 30 MS patients, 21 neurosarcoid patients, and 4 ADEM patients.
Mean apparent diffusion coefficients were significantly higher in MS patients than in non-MS patients in 6 of 6 of the corpus callosal regions assessed but not in any of the non-callosal white or gray matter regions assessed.
Elevated apparent diffusion coefficients within the corpus callosum on diffusion weighted imaging may potentially help differentiate between patients with MS and patients with other diseases affecting the central nervous system white matter.
比较被诊断为多发性硬化症（MS）的患者与被诊断为继发性脱髓鞘疾病（如神经结节病和急性播散性脑脊髓炎（ADEM））的患者脑灰质和白质区域的扩散加权成像指标。
对30例MS患者、21例神经结节病患者和4例ADEM患者进行扩散加权扫描，并测定12个感兴趣区域的表观扩散系数。
在所评估的胼胝体区域的6个区域中，MS患者的平均表观扩散系数显著高于非MS患者，但在所评估的非胼胝体白质或灰质区域中均未出现这种情况。
扩散加权成像时胼胝体内表观扩散系数升高可能有助于鉴别MS患者与其他影响中枢神经系统白质的疾病患者。
