Crystal structure of the DNA gyrase GyrA N-terminal domain from Mycobacterium tuberculosis.
作者信息
Tretter Elsa M, Schoeffler Allyn J, Weisfield Shellie R, Berger James M
机构信息
Division of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720-3220, USA.
出版信息
Proteins. 2010 Feb 1;78(2):492-5. doi: 10.1002/prot.22600.
Abstract
摘要
相似文献
1
Crystal structure of the DNA gyrase GyrA N-terminal domain from Mycobacterium tuberculosis.结核分枝杆菌DNA促旋酶GyrA N端结构域的晶体结构
Proteins. 2010 Feb 1;78(2):492-5. doi: 10.1002/prot.22600.
2
Mycobacterium tuberculosis DNA gyrase possesses two functional GyrA-boxes.结核分枝杆菌 DNA 回旋酶具有两个功能 GyrA 盒。
Biochem J. 2013 Nov 1;455(3):285-94. doi: 10.1042/BJ20130430.
3
A superhelical spiral in the Escherichia coli DNA gyrase A C-terminal domain imparts unidirectional supercoiling bias.大肠杆菌DNA促旋酶A C末端结构域中的超螺旋螺旋赋予单向超螺旋偏向性。
J Biol Chem. 2005 Jul 15;280(28):26177-84. doi: 10.1074/jbc.M502838200. Epub 2005 May 15.
4
The key DNA-binding residues in the C-terminal domain of Mycobacterium tuberculosis DNA gyrase A subunit (GyrA).结核分枝杆菌DNA回旋酶A亚基（GyrA）C末端结构域中的关键DNA结合残基。
Nucleic Acids Res. 2006;34(19):5650-9. doi: 10.1093/nar/gkl695. Epub 2006 Oct 11.
5
Crystallization and preliminary crystallographic studies of Mycobacterium tuberculosis DNA gyrase B C-terminal domain, part of the enzyme reaction core.结核分枝杆菌DNA回旋酶B C末端结构域（酶反应核心的一部分）的结晶及初步晶体学研究
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Apr 1;65(Pt 4):350-2. doi: 10.1107/S1744309109006575. Epub 2009 Mar 21.
6
Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding.氟喹诺酮-拓扑异构酶-DNA 复合物：两种药物结合模式。
J Biol Chem. 2014 May 2;289(18):12300-12. doi: 10.1074/jbc.M113.529164. Epub 2014 Feb 4.
7
A new crystal structure of the bifunctional antibiotic simocyclinone D8 bound to DNA gyrase gives fresh insight into the mechanism of inhibition.新型双联抗生素西蒙菌素 D8 与 DNA 拓扑异构酶复合物的晶体结构为其抑制机制提供了新的见解。
J Mol Biol. 2014 May 15;426(10):2023-33. doi: 10.1016/j.jmb.2014.02.017. Epub 2014 Mar 1.
8
Mutagenesis in the alpha3alpha4 GyrA helix and in the Toprim domain of GyrB refines the contribution of Mycobacterium tuberculosis DNA gyrase to intrinsic resistance to quinolones.结核分枝杆菌DNA促旋酶α3α4 GyrA螺旋区和GyrB的Toprim结构域中的诱变作用，进一步明确了结核分枝杆菌DNA促旋酶对喹诺酮类药物内在耐药性的影响。
Antimicrob Agents Chemother. 2008 Aug;52(8):2909-14. doi: 10.1128/AAC.01380-07. Epub 2008 Apr 21.
9
The role of Ca²⁺ in the activity of Mycobacterium tuberculosis DNA gyrase.钙（Ca²⁺）在结核分枝杆菌 DNA 回旋酶活性中的作用。
Nucleic Acids Res. 2012 Oct;40(19):9774-87. doi: 10.1093/nar/gks704. Epub 2012 Jul 27.
10
Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity.结核分枝杆菌 DNA 回旋酶的整体结构揭示了棒状杆菌科特异性插入在 ATP 酶活性中的作用。
Structure. 2019 Apr 2;27(4):579-589.e5. doi: 10.1016/j.str.2019.01.004. Epub 2019 Feb 7.
引用本文的文献
1
A chlorinated diketopiperazine antibiotic targets .一种氯化二酮哌嗪抗生素靶向……
Antimicrob Agents Chemother. 2025 Sep 3;69(9):e0036925. doi: 10.1128/aac.00369-25. Epub 2025 Jul 31.
2
Structural insight in understanding the impact of mutation at position 88 and 94 of DNA gyrase A of Mycobacterium tuberculosis in developing resistance against delafloxacin.在理解结核分枝杆菌DNA促旋酶A第88位和第94位突变对德拉氟沙星耐药性产生的影响方面的结构见解。
J Biol Phys. 2025 Jun 10;51(1):21. doi: 10.1007/s10867-025-09686-6.
3
Signal Propagation in the ATPase Domain of DNA Gyrase from Dynamical-Nonequilibrium Molecular Dynamics Simulations.从非平衡动力学分子动力学模拟研究 DNA 拓扑异构酶 ATPase 结构域中的信号传导。
Biochemistry. 2024 Jun 4;63(11):1493-1504. doi: 10.1021/acs.biochem.4c00161. Epub 2024 May 14.
4
Pharmacophore modeling, docking and the integrated use of a ligand- and structure-based virtual screening approach for novel DNA gyrase inhibitors: synthetic and biological evaluation studies.新型DNA促旋酶抑制剂的药效团建模、对接以及基于配体和结构的虚拟筛选方法的综合应用：合成与生物学评价研究
RSC Adv. 2021 Oct 25;11(55):34462-34478. doi: 10.1039/d1ra05630a.
5
Wicked: The untold story of ciprofloxacin.《邪恶：环丙沙星的隐秘故事》
PLoS Pathog. 2018 Mar 1;14(3):e1006805. doi: 10.1371/journal.ppat.1006805. eCollection 2018 Mar.
6
Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.结核分枝杆菌中gyrase-氟喹诺酮切割复合物的晶体结构与稳定性
Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1706-13. doi: 10.1073/pnas.1525047113. Epub 2016 Jan 20.
7
Association of gyrA/B mutations and resistance levels to fluoroquinolones in clinical isolates of Mycobacterium tuberculosis.结核分枝杆菌临床分离株中gyrA/B基因突变与对氟喹诺酮类药物耐药水平的关联
Emerg Microbes Infect. 2014 Mar;3(3):e19. doi: 10.1038/emi.2014.21. Epub 2014 Mar 12.
8
The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action.萘醌二蒽酮是一种拓扑异构酶 II 抑制剂，具有新颖的作用机制。
J Biol Chem. 2013 Feb 15;288(7):5149-56. doi: 10.1074/jbc.M112.419069. Epub 2012 Dec 28.
9
Withdrawn.撤回。
Infect Disord Drug Targets. 2012 Nov 16.
10
The role of Ca²⁺ in the activity of Mycobacterium tuberculosis DNA gyrase.钙（Ca²⁺）在结核分枝杆菌 DNA 回旋酶活性中的作用。
Nucleic Acids Res. 2012 Oct;40(19):9774-87. doi: 10.1093/nar/gks704. Epub 2012 Jul 27.
本文引用的文献
1
Processing of X-ray diffraction data collected in oscillation mode.振荡模式下收集的X射线衍射数据的处理。
Methods Enzymol. 1997;276:307-26. doi: 10.1016/S0076-6879(97)76066-X.
2
Phaser crystallographic software.相位结晶学软件。
J Appl Crystallogr. 2007 Aug 1;40(Pt 4):658-674. doi: 10.1107/S0021889807021206. Epub 2007 Jul 13.
3
Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases.对IIA型拓扑异构酶喹诺酮-DNA切割复合物的结构洞察。
Nat Struct Mol Biol. 2009 Jun;16(6):667-9. doi: 10.1038/nsmb.1604. Epub 2009 May 17.
4
DNA topoisomerases: harnessing and constraining energy to govern chromosome topology.DNA拓扑异构酶：利用和控制能量以调控染色体拓扑结构
Q Rev Biophys. 2008 Feb;41(1):41-101. doi: 10.1017/S003358350800468X.
5
Structural basis for gate-DNA recognition and bending by type IIA topoisomerases.IIA型拓扑异构酶对门控DNA识别与弯曲的结构基础
Nature. 2007 Dec 20;450(7173):1201-5. doi: 10.1038/nature06396.
6
The structural basis for substrate specificity in DNA topoisomerase IV.DNA拓扑异构酶IV中底物特异性的结构基础。
J Mol Biol. 2005 Aug 19;351(3):545-61. doi: 10.1016/j.jmb.2005.06.029.
7
Coot: model-building tools for molecular graphics.Coot：分子图形的模型构建工具。
Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32. doi: 10.1107/S0907444904019158. Epub 2004 Nov 26.
8
Suite of three protein crystallography beamlines with single superconducting bend magnet as the source.由单个超导弯曲磁体作为光源的三条蛋白质晶体学光束线组合。
J Synchrotron Radiat. 2004 Nov 1;11(Pt 6):447-55. doi: 10.1107/S0909049504024835. Epub 2004 Oct 22.
9
Structure validation by Calpha geometry: phi,psi and Cbeta deviation.通过Cα几何结构进行结构验证：φ、ψ和Cβ偏差。
Proteins. 2003 Feb 15;50(3):437-50. doi: 10.1002/prot.10286.
10
PHENIX: building new software for automated crystallographic structure determination.PHENIX：用于自动晶体结构测定的新软件构建
Acta Crystallogr D Biol Crystallogr. 2002 Nov;58(Pt 11):1948-54. doi: 10.1107/s0907444902016657. Epub 2002 Oct 21.
Zotero 插件