咪唑克生可降低下丘脑腹内侧核及弓状核-正中隆起中的孕激素受体。

Progestin receptors in the ventromedial nucleus of the hypothalamus and arcuate nucleus-median eminence are decreased by idazoxan.

作者信息

Vincent P A, Feder H H

机构信息

Institute of Animal Behavior, Rutgers University, Newark, NJ 07102.

出版信息

Brain Res. 1990 Sep 24;528(1):95-8. doi: 10.1016/0006-8993(90)90199-l.

DOI:10.1016/0006-8993(90)90199-l

PMID:1978797

Abstract

Steroid-dependent lordosis behavior in ovariectomized (OVX) guinea pigs is attenuated by alpha 1- and/or alpha 2-noradrenergic (NE) receptor antagonists. Correlated with the decrease in lordosis after alpha 1-NE receptor blockade by prazosin is a decrease in 'cytosol' progestin receptors in the ventromedial hypothalamic nucleus (VMN). We examined whether a presumed alpha 2-NE receptor blocker (idazoxan, IDA) also affects progestin receptors. A decrease in 'cytosol' progestin receptors was found after IDA treatment of OVX, estrogen-treated guinea pigs in the VMN and the arcuate nucleus-median eminence (ARC-ME). Apparently, either prazosin or IDA can inhibit lordosis behavior and decrease 'cytosol' progestin receptors in the VMN. In contrast, idazoxan but not prazosin, decrease 'cytosol' progestin receptors in the ARC-ME.

摘要

α1和/或α2去甲肾上腺素能（NE）受体拮抗剂可减弱去卵巢（OVX）豚鼠的类固醇依赖性脊柱前凸行为。与哌唑嗪阻断α1-NE受体后脊柱前凸减少相关的是腹内侧下丘脑核（VMN）中“胞质溶胶”孕激素受体的减少。我们研究了一种假定的α2-NE受体阻滞剂（咪唑克生，IDA）是否也会影响孕激素受体。在对OVX、经雌激素处理的豚鼠进行IDA治疗后，发现VMN以及弓状核-正中隆起（ARC-ME）中的“胞质溶胶”孕激素受体减少。显然，哌唑嗪或IDA均可抑制脊柱前凸行为并降低VMN中的“胞质溶胶”孕激素受体。相比之下，咪唑克生而非哌唑嗪可降低ARC-ME中的“胞质溶胶”孕激素受体。