Thornton J E, Nock B, McEwen B S, Feder H H
Brain Res. 1986 Jul 2;377(1):155-9. doi: 10.1016/0006-8993(86)91200-x.
The concentration of estrogen-induced cytosolic progestin receptors (CPRs) in the hypothalamus of alpha 1-noradrenergic antagonist-treated female guinea pigs is reduced relative to non-drug-treated controls. The present study determined where within the hypothalamus this reduction occurs. Ovariectomized, estradiol-treated guinea pigs were given either the alpha 1-noradrenergic antagonist prazosin or vehicle. Microdissected brain regions were assayed for CPR levels. Prazosin caused a selective relative decrease in CPR levels of the ventromedial nucleus of the hypothalamus. No significant effects of prazosin were seen in other hypothalamic or preoptic area nuclei.
与未接受药物治疗的对照组相比，α1-去甲肾上腺素能拮抗剂处理的雌性豚鼠下丘脑内雌激素诱导的胞质孕激素受体（CPR）浓度降低。本研究确定了这种降低发生在下丘脑的哪个部位。对去卵巢、接受雌二醇治疗的豚鼠给予α1-去甲肾上腺素能拮抗剂哌唑嗪或赋形剂。对显微切割的脑区进行CPR水平检测。哌唑嗪导致下丘脑腹内侧核CPR水平选择性相对降低。在其他下丘脑或视前区核中未观察到哌唑嗪的显著作用。
