Xu Jing, Zhou Xiao-Li, Zhang Hao, Deng Chong, Zhang Yan, Li Zhen
School of Forensic Medicine, Kunming Medical College, Kunming 650031, China.
Fa Yi Xue Za Zhi. 2009 Aug;25(4):282-5.
Amphetamine-type stimulants (ATS) is the most widespread narcotics in the 21st century. The methamphetamine's intoxication mechanism, psychological dependence, drug resistance and therapeutic drug development are the hot spots in current research. Establishment of animal model with methamphetamine poisoning is the basic for the relative studies, the normalization and standardization of the animal model settles the foundation for methamphetamine's further research. This article reviews the animal model of methamphetamine poisoning in China and abroad, the brief history of the acute, subacute and chronic animal model of methamphetamine poisoning, as well as the principles and methods of the animal model establishment and its evaluation criteria. The necessity, significance and its scientific expansion of performing experimental research on the methamphetamine poisoning animal model are also discussed.
苯丙胺类兴奋剂（ATS）是21世纪分布最为广泛的毒品。甲基苯丙胺的中毒机制、心理依赖、耐药性及治疗药物研发是当前研究的热点。建立甲基苯丙胺中毒动物模型是相关研究的基础，动物模型的规范化和标准化为甲基苯丙胺的深入研究奠定了基础。本文综述了国内外甲基苯丙胺中毒动物模型，甲基苯丙胺急性、亚急性和慢性中毒动物模型的简史，以及动物模型的建立原则、方法及其评价标准。还讨论了对甲基苯丙胺中毒动物模型进行实验研究的必要性、意义及其科学拓展。
