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抑制缺氧反应用于癌症治疗：新出现的方法。

Inhibiting the hypoxia response for cancer therapy: the new kid on the block.

作者信息

Koh Mei Yee, Spivak-Kroizman Taly R, Powis Garth

机构信息

Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, Texas, USA.

出版信息

Clin Cancer Res. 2009 Oct 1;15(19):5945-6. doi: 10.1158/1078-0432.CCR-09-1650. Epub 2009 Sep 29.

DOI:10.1158/1078-0432.CCR-09-1650
PMID:19789327
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2760048/
Abstract

The hypoxia-inducible transcription factor (HIF)-1alpha inhibitor KC7F2 described in this issue of Clinical Cancer Research is the newest addition to an emerging class of antitumor agents targeting the hypoxia response. Here, we discuss the proposed mechanism of action of KC7F2 and its potential strengths and limitations in comparison with other promising HIF-1alpha inhibitors.

摘要

本期《临床癌症研究》中描述的缺氧诱导转录因子（HIF）-1α抑制剂KC7F2是靶向缺氧反应的新型抗肿瘤药物中的最新成员。在此，我们讨论了KC7F2的作用机制，以及与其他有前景的HIF-1α抑制剂相比，它潜在的优势和局限性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d59d/2760048/968a6f846cdc/nihms135385f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d59d/2760048/968a6f846cdc/nihms135385f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d59d/2760048/968a6f846cdc/nihms135385f1.jpg

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A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1{alpha}.YC-1抑制缺氧诱导因子（HIF）的一种新作用模式：刺激FIH依赖的p300与HIF-1α解离。
Mol Cancer Ther. 2008 Dec;7(12):3729-38. doi: 10.1158/1535-7163.MCT-08-0074.
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Effects of 4E-BP1 expression on hypoxic cell cycle inhibition and tumor cell proliferation and survival.
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Acta Pharmacol Sin. 2023 May;44(5):940-953. doi: 10.1038/s41401-022-01014-1. Epub 2022 Nov 10.
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A Novel Hypoxia-inducible Factor 1α Inhibitor KC7F2 Attenuates Oxygen-induced Retinal Neovascularization.一种新型缺氧诱导因子 1α 抑制剂 KC7F2 可减轻氧诱导的视网膜新生血管形成。
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