Department of Radiology, Medical Faculty, Suleyman Demirel University, Isparta, Turkey.
Biol Trace Elem Res. 2010 Aug;136(2):140-8. doi: 10.1007/s12011-009-8528-1. Epub 2009 Sep 30.
X-ray radiation is detrimental to human cells and may lead to development of life-threatening diseases. Cigarette paper and cigarette smoke contain toxic elements, whereas vitamins C and E (VCE) may have regulator effects on the elements. We investigated effects of VCE administration on X-ray-induced element changes in blood of smoker and nonsmoker X-ray technicians. Twenty technicians and 30 healthy age-matched control subjects were used in the study. Ten of the X-ray technicians and 15 of the control were smokers. Blood serum samples were taken from the control. Oral vitamins C (500 mg) and E (150 mg) were supplemented daily to the smoker and nonsmoker X-ray technicians for 5 weeks. Serum samples were taken from the X-ray technicians before and after 5 weeks. Copper, zinc, selenium, aluminum, iron, magnesium, and calcium levels were investigated in control and X-ray technicians, both smokers and nonsmokers. Copper, zinc, and selenium levels were lower in the total X-ray group and smoker X-ray group than in control and nonsmoker X-ray group, although iron, magnesium, and calcium levels were higher in X-ray group than in control. The copper, zinc, selenium, and aluminum levels were higher in the VCE treatment group than those in X-ray group, although magnesium and calcium levels were decreased by the treatment. The serum zinc, copper, selenium, and magnesium levels were lower in smoker control group when compared to nonsmoker control group. The serum zinc levels were lower in smoker X-ray group than nonsmoker X-ray group, although iron level was higher in smoker X-ray group than in nonsmoker X-ray group. VCE prevents the smoke and X-ray-induced selenium, zinc, magnesium, and copper decrease to strengthen the antioxidant trace element levels in the serum of the technicians.
X 射线辐射对人体细胞有害，并可能导致危及生命的疾病的发展。卷烟纸和香烟烟雾中含有有毒元素，而维生素 C 和 E（VCE）可能对这些元素具有调节作用。我们研究了 VCE 给药对吸烟者和非吸烟者 X 射线技术员血液中 X 射线诱导的元素变化的影响。该研究使用了 20 名技术员和 30 名年龄匹配的健康对照者。10 名 X 射线技术员和 15 名对照者为吸烟者。从对照者中抽取血清样本。吸烟者和非吸烟者 X 射线技术员每天口服维生素 C（500mg）和 E（150mg），持续 5 周。在 5 周前后从 X 射线技术员中抽取血清样本。在控制组和 X 射线技术员中，包括吸烟者和非吸烟者，都检测了铜、锌、硒、铝、铁、镁和钙的水平。总的 X 射线组和吸烟者 X 射线组的铜、锌和硒水平低于对照组和非吸烟者 X 射线组，而 X 射线组的铁、镁和钙水平高于对照组。与 X 射线组相比，VCE 治疗组的铜、锌、硒和铝水平较高，尽管治疗后镁和钙水平下降。与非吸烟者对照组相比，吸烟者对照组的血清锌、铜、硒和镁水平较低。与非吸烟者 X 射线组相比，吸烟者 X 射线组的血清锌水平较低，尽管铁水平在吸烟者 X 射线组中较高。VCE 可防止烟雾和 X 射线诱导的硒、锌、镁和铜减少，从而增强技术员血清中的抗氧化微量营养素水平。
