Rheumatology Unit, Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, UNICAMP, Campinas, SP, 13083-970, Brazil.
Rheumatol Int. 2010 Nov;30(12):1669-72. doi: 10.1007/s00296-009-1133-y. Epub 2009 Sep 30.
A 43-year-old woman reported pain in the right hypochondrium, which had started 3 years before and had been worsening for the past few days. Claudication in the superior and inferior limbs, diffuse myalgia, dyspnea, precordialgia followed by dizziness and visual turbidity were added to the clinical picture. In the physical examination bilateral carotid bruit was observed, abdominal aorta murmur and the decrease of the right radial and left pedis pulses and arterial hypertension with difference in the diastolic pressure between limbs >10 mmHg was also observed. On cardiac catheterisation with aortography, right coronary with proximal parietal irregularities, slight pressure increase in right chambers and pulmonary artery, preserved left ventricle contractility, competent valves, carotid and subclavian partial obstruction, severe narrowing of the abdominal aorta below the diaphragm (80%) and right renal artery significant stenosis were observed. Takayasu's arteritis (TA) diagnosis was established according to the ACR criteria based on the clinical symptomatology, on physical and image test findings. Two years later she presented malar rash, photosensitivity, nephropathy, leukopenia, lymphopenia and hemolytic anemia confirming the systemic lupus erythematosus (SLE) diagnosis. TA coexisting with SLE has rarely been reported.
一位 43 岁女性报告右季肋部疼痛,该疼痛始于 3 年前,且在过去几天逐渐加重。临床症状还包括四肢跛行、弥漫性肌肉痛、呼吸困难、胸痛,继之出现头晕和视力模糊。体格检查发现双侧颈动脉杂音、腹主动脉杂音以及右侧桡动脉和左侧足背动脉搏动减弱,四肢舒张压差值>10mmHg,存在高血压。行心血管造影的心脏导管检查发现,右冠状动脉近端壁不规则,右心房压力轻度升高,左心室收缩功能正常,瓣叶功能良好,颈动脉和锁骨下动脉部分阻塞,膈下腹主动脉严重狭窄(80%),右肾动脉显著狭窄。根据 ACR 标准,基于临床症状、体格检查和影像学检查结果,诊断为 Takayasu 动脉炎(TA)。两年后,她出现了蝶形红斑、光过敏、肾病、白细胞减少、淋巴细胞减少和溶血性贫血,从而确诊系统性红斑狼疮(SLE)。TA 合并 SLE 非常罕见。