Rolla G, Bucca C, Bugiani M, Oliva A, Branciforte L
Dipartimento di Scienze Biomediche e Oncologia Umana, University of Torino, Italia.
Magnes Trace Elem. 1990;9(3):132-6.
In 95 patients with severe chronic airway obstruction (FEV1 33.2 +/- 12% of predicted; mean +/- SE), we investigated whether drug therapy had any influence on serum Mg levels. 11/95 patients had a serum Mg less than 1.45 mEq/l (lower normal limit). Multiple-regression analysis showed that the use of diuretics was associated with a significantly lower serum Mg level (1.59 +/- CI 0.06 mEq/l vs. an adjusted mean of 1.71 mEq/l; F = 11, 2, p less than 0.001). There was a significant negative correlation between serum Mg and the length of oral steroid therapy (1.64 +/- CI 0.02 mEq/l for less than 24 months of therapy vs. 1.52 +/- CI 0.06 mEq/l for greater than 24 months of therapy; F = 7, 3, p less than 0.005). No effect of theophylline, inhaled steroids or beta 2-agonists on serum Mg was observed. Because of potential negative effects of hypomagnesemia on respiratory function, routine serum magnesium determination is recommended in patients with chronic obstructive lung disease taking diuretic drugs or corticosteroids.
在95例严重慢性气道阻塞患者（第一秒用力呼气容积[FEV1]为预测值的33.2±12%；均值±标准误）中，我们研究了药物治疗是否对血清镁水平有任何影响。95例患者中有11例血清镁低于1.45 mEq/L（正常下限）。多元回归分析显示，使用利尿剂与血清镁水平显著降低相关（1.59±可信区间0.06 mEq/L，而校正均值为1.71 mEq/L；F=11, 2，p<0.001）。血清镁与口服类固醇治疗的时长之间存在显著负相关（治疗时间少于24个月时为1.64±可信区间0.02 mEq/L，治疗时间超过24个月时为1.52±可信区间0.06 mEq/L；F=7, 3，p<0.005）。未观察到茶碱、吸入性类固醇或β2激动剂对血清镁有影响。由于低镁血症对呼吸功能可能存在负面影响，建议对服用利尿剂或皮质类固醇的慢性阻塞性肺疾病患者进行常规血清镁测定。
