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[梗阻性肥厚型心肌病的室间隔心肌切除术:金标准]

[Septal myectomy for obstructive hypertrophic cardiomyopathy: the gold standard].

作者信息

Dearani Joseph A, Schaff Hartzell V, Ommen Steve R

机构信息

Division of Cardiovascular Surgery, Mayo Clinic and Foundation, Minnesota 55905, USA.

出版信息

Zhonghua Xin Xue Guan Bing Za Zhi. 2009 Apr;37(4):307-11.

Abstract

Septal myectomy effectively and definitively relieves LVOT obstruction and cardiac symptoms in adults and children with obstructive hypertrophic cardiomyopathy (HCM). Abnormalities of the mitral valve can be addressed without the need for mitral valve replacement in almost all circumstances. Concomitant mitral valve repair for myxomatous disease requires minor modifications when performed in conjunction with septal myectomy; mitral valve replacement is rarely necessary. In experienced centers, early mortality for isolated septal myectomy is low (approximately 1%) and overall results are excellent and continue to improve in the current era. Symptomatic improvement with myectomy is expected for most; 90% of patients improve by at least one functional class, and most remain improved on late follow-up. Late survivorship is improved compared to nonoperated patients with obstructive HCM, and myectomy may be associated with reduced risk of sudden cardiac death. These results should serve as the gold standard and a basis for comparison with newer nonsurgical modalities, i. e., septal alcohol ablation.

摘要

室间隔心肌切除术能有效且彻底地缓解梗阻性肥厚型心肌病(HCM)成人和儿童患者的左心室流出道梗阻及心脏症状。在几乎所有情况下,二尖瓣异常无需进行二尖瓣置换即可得到处理。黏液瘤病合并二尖瓣修复术与室间隔心肌切除术同时进行时,需要做一些小的调整;很少需要进行二尖瓣置换。在经验丰富的中心,单纯室间隔心肌切除术的早期死亡率较低(约1%),总体效果良好,且在当前时代仍在不断改善。大多数患者行心肌切除术后症状有望改善;90%的患者功能分级至少提高一级,且大多数患者在后期随访中仍保持改善状态。与未接受手术的梗阻性HCM患者相比,晚期生存率有所提高,心肌切除术可能与心脏性猝死风险降低有关。这些结果应作为金标准以及与更新的非手术方式(即酒精间隔消融术)进行比较的基础。

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