Wiedosari E, Copeman D B
Research Institute for Veterinary Science, Bogor, Indonesia.
Vet Parasitol. 1990 Oct;37(2):101-11. doi: 10.1016/0304-4017(90)90065-j.
Innate resistance of Javanese thin-tailed sheep to Fasciola gigantica was investigated in animals infected with single doses of 150 or 500 metacercariae and killed 4, 8, 12 or 16 weeks after infection. Infected and non-infected sheep had similar values for packed cell volume, mean corpuscular volume, mean corpuscular haemoglobin concentration, serum glutamate dehydrogenase, serum gamma glutamyl transferase and serum aspartate transferase throughout the trial, except for one animal infected with 500 metacercariae from which the highest recovery of flukes (55) was made. This animal developed pathologically altered values from 12 weeks post infection, coincident with the period of greatest hepatic haemorrhage and destruction of hepatic tissue by migrating flukes and their entry into bile ducts. However, values were altered much less than those reported in other sheep given as few as 200 metacercaria of F. gigantica. Both susceptibility to infection with F. gigantica, as indicated by percentage take of metacercariae and the severity of pathological changes were low in this study in comparison with reports involving other breeds of sheep infected with this parasite. These findings support the conclusion that Javanese thin-tailed sheep have a high innate resistance to F. gigantica.
对感染单剂量150或500个囊蚴并在感染后4、8、12或16周处死的爪哇细尾绵羊对巨片吸虫的先天抵抗力进行了研究。在整个试验过程中，感染和未感染的绵羊在血细胞比容、平均红细胞体积、平均红细胞血红蛋白浓度、血清谷氨酸脱氢酶、血清γ-谷氨酰转移酶和血清天冬氨酸转移酶方面的值相似，但有一只感染500个囊蚴的绵羊除外，该绵羊体内的吸虫回收率最高（55条）。这只绵羊在感染后12周出现了病理改变的值，这与吸虫迁移导致肝脏大出血和肝组织破坏以及吸虫进入胆管的时期一致。然而，与其他仅感染200个巨片吸虫囊蚴的绵羊相比，其值的改变要小得多。与涉及感染该寄生虫的其他品种绵羊的报告相比，本研究中巨片吸虫感染的易感性（以囊蚴感染率表示）和病理变化的严重程度均较低。这些发现支持了爪哇细尾绵羊对巨片吸虫具有高度先天抵抗力这一结论。
