Wiedosari E, Graydon R, Copeman D B
Research Institute for Veterinary Science, Bogor, Indonesia.
J Comp Pathol. 1991 Aug;105(2):147-55. doi: 10.1016/s0021-9975(08)80070-9.
Pathological changes in the liver induced by Fasciola gigantica and Gigantocotyle explanatum were readily distinguishable from each other. Lesions associated with the migration of immature flukes through the parenchyma were a prominent feature of infection with Fasciola gigantica, whereas lesions induced by Gigantocotyle explanatum were confined to the large bile ducts. The size of the hepatic lesions increased during the course of infection with Fasciola gigantica and was associated with the formation of progressively larger areas of scar tissue in the parenchymal migration tracts as the flukes grew. This was also as a result of the progressively increasing cellular infiltration, proliferation of bile ductules and fibrosis which occurred in adjacent portal triads and interlobular septa. The absence of signs of migration through the hepatic parenchyma by Gigantocotyle explanatum, was regarded as evidence that these flukes gain entry to the bile ducts from the intestine via the common bile duct. In bile ducts infected with Fasciola gigantica there was more extensive desquamation of the epithelium, more intense mucosal infiltration with lymphoid cells and fewer eosinophils, less severe glandular hyperplasia, more free blood in the lumen and a thicker duct wall than in bile ducts infected with Gigantocotyle explanatum.
巨片形吸虫和扩展巨盘吸虫所致肝脏的病理变化很容易相互区分。未成熟吸虫穿过实质组织移行相关的病变是巨片形吸虫感染的一个显著特征，而扩展巨盘吸虫所致病变局限于大胆管。在巨片形吸虫感染过程中，肝脏病变的大小会增加，并且随着吸虫生长，在实质组织移行路径中会形成逐渐增大的瘢痕组织区域。这也是相邻门三联体和小叶间隔中细胞浸润逐渐增加、胆小管增生和纤维化的结果。扩展巨盘吸虫没有穿过肝实质移行的迹象，这被视为这些吸虫从肠道经胆总管进入胆管的证据。与感染扩展巨盘吸虫的胆管相比，感染巨片形吸虫的胆管上皮有更广泛的脱落、黏膜有更强烈的淋巴细胞浸润且嗜酸性粒细胞较少、腺体增生较轻、管腔内有更多游离血液且管壁更厚。
