Amir S, Schiavetto A, Pollock R
Department of Psychology, Concordia University, Montreal, Que., Canada.
Brain Res. 1990 Sep 17;527(2):326-9. doi: 10.1016/0006-8993(90)91153-8.
Selective stimulation of ventromedial hypothalamic nucleus (VMH) neurons by microinjection of the excitatory amino acid glutamate sharply increased interscapular brown adipose tissue (IBAT) and core temperatures in urethane-anaesthetized rats. This effect was blocked by co-injection of insulin (0.1-1 microgram) though not an inactive insulin analog, TNB3 insulin. Injection of insulin (1 microgram) into the contralateral VMH or systemic administration of insulin (1 microgram) had no effect on the thermogenic response to intra-VMH glutamate. These results complement those showing that intra-VMH insulin suppresses the basal firing rate of sympathetic nerves to IBAT and diminishes cold-induced nonshivering thermogenesis in BAT and add support to the view that insulin functions as an inhibitory signal on VMH neurons controlling thermogenesis in BAT.
通过微量注射兴奋性氨基酸谷氨酸对腹内侧下丘脑核（VMH）神经元进行选择性刺激，可使乌拉坦麻醉大鼠的肩胛间棕色脂肪组织（IBAT）和核心温度急剧升高。这种效应可被共同注射胰岛素（0.1 - 1微克）阻断，但不能被无活性的胰岛素类似物TNB3胰岛素阻断。向对侧VMH注射胰岛素（1微克）或全身性给予胰岛素（1微克）对VMH内谷氨酸引起的产热反应没有影响。这些结果补充了那些表明VMH内胰岛素抑制支配IBAT的交感神经的基础放电率并减少BAT中冷诱导的非寒战产热的研究结果，并支持胰岛素作为控制BAT产热的VMH神经元上的抑制信号发挥作用的观点。
