Amir S, Shizgal P, Rompré P P
Department of Psychology, Concordia University, Montreal, Que, Canada.
Brain Res. 1989 Sep 25;498(1):140-4. doi: 10.1016/0006-8993(89)90409-5.
Injection of glutamate (100 mM to 1 M, in 0.25 micrograms saline) into the hypothalamic suprachiasmatic nucleus (SCN) dose-dependently increased interscapular brown adipose tissue (IBAT) and core temperatures in the urethane-anaesthetized rat. This effect was more pronounced in rats tested during the light-off period than in animals tested during the light-on period. Prior injection of the local anaesthetic, procaine (5% in 0.5 microliter saline), into the ipsilateral ventromedial hypothalamic nucleus (VMH) attenuated the increases in IBAT and core temperatures induced by intra-SCN glutamate. The VMH has previously been implicated in the central regulation of BAT thermogenesis; the present results suggest the pathway arising in the SCN exerts an excitatory influence on VMH neurons involved in the control of BAT function.
向乌拉坦麻醉的大鼠下丘脑视交叉上核（SCN）注射谷氨酸（100 mM至1 M，溶于0.25微克生理盐水中），可使肩胛间棕色脂肪组织（IBAT）和核心体温呈剂量依赖性升高。这种效应在熄灯期测试的大鼠中比在开灯期测试的动物中更为明显。事先向同侧腹内侧下丘脑核（VMH）注射局部麻醉剂普鲁卡因（0.5微升生理盐水中含5%），可减弱SCN内谷氨酸诱导的IBAT和核心体温升高。VMH先前被认为参与棕色脂肪组织产热的中枢调节；目前的结果表明，起源于SCN的通路对参与控制棕色脂肪组织功能的VMH神经元产生兴奋性影响。
