Kovalev G I, Prikhozhan A V, Raevskiĭ K S
Farmakol Toksikol. 1990 Sep-Oct;53(5):22-4.
In the experiments on the superfused synaptosomes of the rat brain cortex it was shown that both typical and atypical neuroleptics in the micromolar range of concentrations decrease K(+)-stimulated 3H-D-aspartate release. Serotonin (10(-5) M) and dopamine (10(-7) M) do not affect D-aspartate release. Serotonin abolishes the action of all typical neuroleptics studied (haloperidol, chlorpromazine, fluphenazine) and of sulpiride and clozapine, but not of carbidine. Dopamine antagonizes only the effect of atypical neuroleptics.
在对大鼠大脑皮层超融合突触体的实验中表明，在微摩尔浓度范围内，典型和非典型抗精神病药物均可降低钾离子刺激的3H-D-天冬氨酸释放。5-羟色胺（10^(-5) M）和多巴胺（10^(-7) M）不影响D-天冬氨酸释放。5-羟色胺可消除所有所研究的典型抗精神病药物（氟哌啶醇、氯丙嗪、氟奋乃静）以及舒必利和氯氮平的作用，但对卡比咪嗪无效。多巴胺仅拮抗非典型抗精神病药物的作用。
