Prikhozhan A V, Kovalev G I, Raevskiĭ K S
Farmakol Toksikol. 1987 Jan-Feb;50(1):10-4.
It was shown in experiments in vitro that neuroleptics haloperidol and sulpiride, antidepressants desipramine and amitriptyline, nootropic agent piracetam, benzodiazepine tranquillizer phenazepam, psychostimulant phenamine and agonist of GABA A-receptors tetrahydroisoxazolopyridinol depending on the concentration in the micromolar range decrease K+-stimulated release of 3H-D-aspartic acid from rat brain cortex synaptosomes. Agonists of GABA B-receptors phenibut and baclofen as well as valproate and sodium oxybutyrate failed to exert a noticeable effect on the process under study.
体外实验表明，抗精神病药物氟哌啶醇和舒必利、抗抑郁药物地昔帕明和阿米替林、促智药吡拉西坦、苯二氮䓬类镇静剂非那西泮、精神兴奋剂苯丙胺以及GABA A受体激动剂四氢异恶唑并吡啶醇，在微摩尔浓度范围内，会根据浓度降低大鼠大脑皮层突触体中K⁺刺激的3H-D-天冬氨酸释放。GABA B受体激动剂苯乙哌啶酮和巴氯芬以及丙戊酸盐和羟丁酸钠对所研究的过程未产生明显影响。
