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草酰乙酸盐补充通过 AMPK/FOXO 依赖途径增加秀丽隐杆线虫的寿命。

Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway.

机构信息

Departments of Pharmacology and Neurosciences, UCSD School of Medicine, University of California-San Diego, La Jolla, CA 92130, USA.

出版信息

Aging Cell. 2009 Dec;8(6):765-8. doi: 10.1111/j.1474-9726.2009.00527.x. Epub 2009 Sep 30.

DOI:10.1111/j.1474-9726.2009.00527.x
PMID:19793063
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2988682/
Abstract

Reduced dietary intake increases lifespan in a wide variety of organisms. It also retards disease progression. We tested whether dietary supplementation of citric acid cycle metabolites could mimic this lifespan effect. We report that oxaloacetate supplementation increased lifespan in Caenorhabditis elegans. The increase was dependent on the transcription factor, FOXO/DAF-16, and the energy sensor, AMP-activated protein kinase, indicating involvement of a pathway that is also required for lifespan extension through dietary restriction. These results demonstrate that supplementation of the citric acid cycle metabolite, oxaloacetate, influences a longevity pathway, and suggest a tractable means of introducing the health-related benefits of dietary restriction.

摘要

减少饮食摄入可以延长多种生物的寿命。它还可以延缓疾病的发展。我们测试了柠檬酸循环代谢物的饮食补充是否可以模拟这种寿命效应。我们报告说，草酰乙酸补充剂可以延长秀丽隐杆线虫的寿命。这种增加依赖于转录因子 FOXO/DAF-16 和能量传感器 AMP 激活蛋白激酶，表明涉及到一条途径，该途径也需要通过饮食限制来延长寿命。这些结果表明，柠檬酸循环代谢物草酰乙酸的补充会影响长寿途径，并为引入饮食限制的健康益处提供了一种可行的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd09/2988682/9c1959573858/nihms200340f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd09/2988682/9c1959573858/nihms200340f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd09/2988682/9c1959573858/nihms200340f1.jpg

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