Datla K P, Bhattacharya S K
Department of Pharmaceutics, Banaras Hindu University, Varanasi, India.
Indian J Exp Biol. 1990 Aug;28(8):792-3.
Regional brain monoamine concentrations were investigated following footshock induced fighting behaviour in paired rats, by a spectrophotofluorometric method. The dopamine (DA) levels of the diencephalon-midbrain (DM), and that of the caudate nucleus (CN), were significantly augmented as compared to unshocked but paired rats, the increase being substantially more in DM. Noradrenaline (NA) concentrations of both DM and pons-medulla (PM) increased to almost similar extents, though the data remained statistically insignificant in comparison to controls. The 5-hydroxytryptamine (5HT) of both DM and PM, however, recorded a decrease, which was statistically significant in the latter brain area. The biochemical data are consonant with the reported facilitatory effect of central DA, and the inhibitory role of central 5HT, in experimental aggression. The observed changes in NA levels, for which a role in experimental aggression remains equivocal, may be due to the stress of footshock kept minimal due to the coping factor of fighting in response to the shock.
采用分光光度荧光法，对成对大鼠足部电击诱发打斗行为后的脑区单胺浓度进行了研究。与未电击但配对的大鼠相比，间脑-中脑（DM）和尾状核（CN）的多巴胺（DA）水平显著升高，DM的升高幅度更大。DM和脑桥-延髓（PM）的去甲肾上腺素（NA）浓度升高程度几乎相似，但与对照组相比，数据在统计学上无显著差异。然而，DM和PM的5-羟色胺（5HT）均有所下降，在后者脑区具有统计学意义。这些生化数据与中枢DA的促进作用以及中枢5HT在实验性攻击行为中的抑制作用的报道一致。NA水平的变化在实验性攻击行为中的作用尚不清楚，这可能是由于应对电击的打斗因素使足部电击的应激保持在最低水平。
