T-2毒素对大鼠和鸡大脑生物源单胺的影响。
Effect of T-2 toxin on brain biogenic monoamines in rats and chickens.
作者信息
Boyd K E, Fitzpatrick D W, Wilson J R, Wilson L M
机构信息
Department of Foods and Nutritition, University of Manitoba, Winnipeg.
出版信息
Can J Vet Res. 1988 Apr;52(2):181-5.
Two experiments were conducted to determine the effect of T-2 toxin on brain biogenic monoamines and their metabolites. Male rats (180 g) and cockerels (28 day, 300 g) were orally dosed with T-2 toxin at 2.5 mg kg-1 body weight. In the first experiment, whole brains were collected 2, 6, 12, 24 and 48 h postdosing and analyzed for monoamines by high performance liquid chromatography with electro-chemical detection. T-2 toxin did not influence whole brain concentrations of monoamines in either species. In the second experiment, brains were collected 24 h postdosing, dissected into five brain regions, and analyzed for monoamines. T-2 toxin treatment resulted in increased serotonin and 5-hydroxy-3-indoleacetic acid in all brain regions of the rat. However, this was not seen in poultry where T-2 toxin treatment resulted in an increase in 5-hydroxy-3-indoleacetic acid, no alteration in serotonin concentration and a decrease in regional norepinephrine and dopamine concentrations. These results suggest that T-2 toxin influences brain biogenic amine metabolism and that there is an intraspecies difference in the central effects of this mycotoxin.
进行了两项实验以确定T-2毒素对脑内生物源性单胺及其代谢产物的影响。将雄性大鼠（180克）和公鸡（28日龄，300克）按2.5毫克/千克体重口服给予T-2毒素。在第一个实验中，给药后2、6、12、24和48小时收集全脑，并通过高效液相色谱-电化学检测法分析单胺。T-2毒素对两种动物的全脑单胺浓度均无影响。在第二个实验中，给药后24小时收集大脑，将其解剖为五个脑区，并分析单胺。T-2毒素处理导致大鼠所有脑区的血清素和5-羟基-3-吲哚乙酸增加。然而，在家禽中未观察到这种情况，T-2毒素处理导致5-羟基-3-吲哚乙酸增加，血清素浓度无变化，区域去甲肾上腺素和多巴胺浓度降低。这些结果表明，T-2毒素影响脑内生物源性胺代谢，并且这种霉菌毒素的中枢效应存在种内差异。
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