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在睾丸癌患者的随访中进行常规阴囊超声检查可更早地发现非同步肿瘤,并提高器官保留率。

Routine scrotal ultrasonography during the follow-up of patients with testicular cancer leads to earlier detection of asynchronous tumours and a high rate of organ preservation.

机构信息

Urology, Medical University Innsbruck, Innsbruck, Austria.

出版信息

BJU Int. 2010 Apr;105(8):1118-20. doi: 10.1111/j.1464-410X.2009.08906.x. Epub 2009 Sep 29.

Abstract

OBJECTIVE

To compare outcomes of patients with asynchronous tumours detected before and after the introduction of scrotal ultrasonography (SUS) during routine follow-up examinations.

PATIENTS AND METHODS

Since January 2001 SUS was also used during the follow-up of patients with testicular cancer. A series of 16 consecutive patients with asynchronous bilateral testicular tumours diagnosed while still complying with routine follow up investigations were identified and divided into two groups; group A was diagnosed by palpation only, before 2001, and group B was diagnosed after 2000. The groups were compared statistically for the interval between asynchronous tumours, clinical stage, tumour diameter at the time of diagnosis and rate of testis-sparing surgery.

RESULTS

All tumours in group A were diagnosed by palpation, but only two in group B were palpable at the time of diagnosis. The mean tumour diameter was statistically significantly smaller in group B (1.2 cm) than in group A (2.68 cm); testis-sparing surgery was used in all of group B and only three patients in group A. After organ-sparing surgery all patients had normal testosterone levels. All patients after organ-sparing surgery had adjuvant scrotal radiotherapy because of germ cell tumour, and no patient had a local recurrence.

CONCLUSION

Our data indicate that using SUS for the remaining testicle in routine follow-up visits of patients with testicular cancer leads to the earlier detection of smaller tumours and, consequently, a higher rate of organ preservation. The maintenance of physiological endocrine function might finally result in a better quality of life.

摘要

目的

比较在常规随访检查中引入阴囊超声(SUS)前后检测到的异步肿瘤患者的结局。

患者和方法

自 2001 年 1 月以来,SUS 也用于睾丸癌患者的随访。确定了一系列连续的 16 例在遵循常规随访研究时诊断出的异步双侧睾丸肿瘤患者,并将其分为两组;组 A 仅通过触诊诊断,在 2001 年之前,组 B 通过触诊和 2000 年之后的 SUS 诊断。对两组患者的异步肿瘤间隔、临床分期、诊断时的肿瘤直径和保留睾丸手术率进行统计学比较。

结果

组 A 中的所有肿瘤均通过触诊诊断,但组 B 中只有 2 个在诊断时可触及。组 B 的肿瘤平均直径明显小于组 A(1.2cm 比 2.68cm);组 B 中所有患者均进行了保留睾丸手术,而组 A 中只有 3 例。保留睾丸手术后,所有患者的睾酮水平均正常。所有保留睾丸手术后的患者均因生殖细胞肿瘤接受了阴囊辅助放疗,且无患者局部复发。

结论

我们的数据表明,在睾丸癌患者的常规随访中使用 SUS 检查对侧睾丸可更早地发现较小的肿瘤,从而提高保留器官的比例。维持生理内分泌功能最终可能会提高生活质量。

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