Lille University Hospital, France.
Diagn Microbiol Infect Dis. 2010 Feb;66(2):169-74. doi: 10.1016/j.diagmicrobio.2009.08.018. Epub 2009 Sep 29.
To assess the incidence of imported malaria in children and to determine the frequency of delayed diagnosis and risk factors for severe malaria, we performed a retrospective multicenter cohort study in the northern region of France and included all children with a positive test for malaria from 2000 to 2006. The incidence of imported malaria in children <18 years, the frequency of a delayed diagnosis, and the risk factors for severe malaria were determined. The study identified 133 children with imported malaria. The mean incidence of this disease was 1.9/100 000 children <18 years (95% confidence interval [CI], 1.6-2.2). Detailed data were available for 120 children. Disease was considered severe in 19% of cases. The diagnosis was delayed (> or =1 day after the first medical contact) in 31% of cases, and this delay was the only independent risk factor identified for severe imported malaria in children (adjusted odds ratio, 3.2; 95% CI, 1.2-8.8; P = 0.02).
为评估儿童输入性疟疾的发病率，并确定延迟诊断的频率和重症疟疾的危险因素，我们在法国北部进行了一项回顾性多中心队列研究，纳入了 2000 年至 2006 年间所有疟原虫检测阳性的儿童。确定了<18 岁儿童输入性疟疾的发病率、延迟诊断的频率和重症疟疾的危险因素。研究共纳入 133 例输入性疟疾患儿。该疾病的平均发病率为 1.9/100000<18 岁儿童（95%可信区间[CI]，1.6-2.2）。120 例患儿有详细数据。19%的患儿被认为患有重症疟疾。31%的患儿存在延迟诊断（首次医疗接触后>或=1 天），这是唯一确定的儿童输入性重症疟疾的独立危险因素（调整比值比，3.2；95%CI，1.2-8.8；P=0.02）。
