Thariat J, Badoual C, Faure C, de Mones E, Butori C, Santini J, Poissonnet G, Maingon P, Faivre S, Klijanienko J, Saint-Guily J Lacau, Righini C A
Département d'Oncologie-Radiothérapie, Centre Antoine-Lacassagne, Université Nice-Sophia-Antipolis, IBDC CNRS UMR 6543, 33 Avenue Valombrose, 06189 Nice Cedex 2, France.
Bull Cancer. 2009 Oct;96(10):989-1004. doi: 10.1684/bdc.2009.0954.
Basaloid squamous cell carcinomas (SCC) are a rare variant of SCC of the head and neck. Their histological characteristics have been described by Wain in 1986 and are reported in the 2005 WHO classification. A poorer prognosis of BSCC has been reported. Two recent case-control studies have shown a higher rate of distant metastases (15-40%, mean over 30%). Conversely, BSCC have similar or better locoregional control rates, a relatively good radiosensitivity and locoregional control. The role of chemotherapy in the neoadjuvant, concomitant or adjuvant setting needs to be redefined due to high metastatic failure rates; chest CT or PET CT are recommended at baseline and every 6-month during follow-up. Some subgroups of BSCC (oropharynx in particular) are more likely to be associated with oncogenic human papilloma virus HPV16. The determination of BSCC head and neck subgroups by HPV status is critical for the prognosis. The basaloid sub-type of squamous cell carcinomas owing to its particular behavior, should be taken into account while deciding the optimal therapeutic strategy.
基底样鳞状细胞癌（SCC）是头颈部鳞状细胞癌的一种罕见变体。其组织学特征于1986年由韦恩描述，并在2005年世界卫生组织分类中有所报道。据报道，基底样鳞状细胞癌的预后较差。最近的两项病例对照研究显示远处转移率较高（15%-40%，平均超过30%）。相反，基底样鳞状细胞癌的局部区域控制率相似或更好，具有相对较好的放射敏感性和局部区域控制效果。由于转移失败率高，化疗在新辅助、同步或辅助治疗中的作用需要重新定义；建议在基线时以及随访期间每6个月进行胸部CT或PET CT检查。基底样鳞状细胞癌的一些亚组（尤其是口咽）更有可能与致癌性人乳头瘤病毒HPV16相关。根据HPV状态确定基底样鳞状细胞癌的头颈部亚组对预后至关重要。鳞状细胞癌的基底样亚型因其特殊行为，在决定最佳治疗策略时应予以考虑。
