Yu G-Y, Gao Y, Peng X, Chen Y, Zhao F-Y, Wu M-J
Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Int J Oral Maxillofac Surg. 2008 Nov;37(11):1003-8. doi: 10.1016/j.ijom.2008.05.019. Epub 2008 Jul 15.
Basaloid squamous cell carcinoma (BSCC) is a rare distinct variant of squamous cell carcinoma (SCC). To investigate its clinical behavior and prognosis, 15 patients with BSCC in the oral and maxillofacial region were clinically analyzed and compared with 15 patients with conventional SCC matched for site, stage, gender and age. To understand its immunohistochemical features, sections for cytokeratin AE1/AE3, CK 13. CK 7, CK 8, proliferating cell nuclear antigen (PCNA) and p53 were reviewed from 12 patients with BSCC. The rate of cervical lymph node metastasis of BSCC was as high as 67% and that of distant metastasis 13%. The tumor recurrence rate was 33% and the 3-year and 5-year survival rates were 53% and 32%, respectively. For conventional SCC, the cervical lymph node metastasis rate was 27%, that of distant metastasis 7%, tumor recurrence rate was 33%, and 3-year and 5-year survival rates were 80% and 70%, respectively. In most BSCC patients (10/12) the PCNA index was over 50%. Twelve BSCC patients were diagnosed with grade II or III conventional SCC when the original records of the primary diagnosis for the 15 patients with BSCC were reviewed. The biological behavior and prognosis of BSCC are similar to those of poorly differentiated SCC.
基底样鳞状细胞癌（BSCC）是一种罕见的独特的鳞状细胞癌（SCC）变体。为了研究其临床行为和预后，对15例口腔颌面部BSCC患者进行了临床分析，并与15例在部位、分期、性别和年龄上相匹配的传统SCC患者进行了比较。为了解其免疫组化特征，对12例BSCC患者的细胞角蛋白AE1/AE3、CK 13、CK 7、CK 8、增殖细胞核抗原（PCNA）和p53切片进行了复查。BSCC的颈部淋巴结转移率高达67%，远处转移率为13%。肿瘤复发率为33%，3年和5年生存率分别为53%和32%。对于传统SCC，颈部淋巴结转移率为27%，远处转移率为7%，肿瘤复发率为33%，3年和5年生存率分别为80%和70%。在大多数BSCC患者（12例中的10例）中，PCNA指数超过50%。当复查15例BSCC患者的原发诊断原始记录时，12例BSCC患者被诊断为II级或III级传统SCC。BSCC的生物学行为和预后与低分化SCC相似。
