Hall Michael P, Band Phillip A, Meislin Robert J, Jazrawi Laith M, Cardone Dennis A
Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, New York, NY 10003, USA.
J Am Acad Orthop Surg. 2009 Oct;17(10):602-8. doi: 10.5435/00124635-200910000-00002.
Platelet-rich plasma is defined as autologous blood with a concentration of platelets above baseline values. Platelet-rich plasma has been used in maxillofacial and plastic surgery since the 1990s; its use in sports medicine is growing given its potential to enhance muscle and tendon healing. In vitro studies suggest that growth factors released by platelets recruit reparative cells and may augment soft-tissue repair. Although minimal clinical evidence is currently available, the use of platelet-rich plasma has increased, given its safety as well as the availability of new devices for outpatient preparation and delivery. Its use in surgery to augment rotator cuff and Achilles tendon repair has also been reported. As the marketing of platelet-rich plasma increases, orthopaedic surgeons must be informed regarding the available preparation devices and their differences. Many controlled clinical trials are under way, but clinical use should be approached cautiously until high-level clinical evidence supporting platelet-rich plasma efficacy is available.
富含血小板血浆被定义为血小板浓度高于基线值的自体血液。自20世纪90年代以来，富含血小板血浆已被用于颌面和整形外科；鉴于其在促进肌肉和肌腱愈合方面的潜力，其在运动医学中的应用正在增加。体外研究表明，血小板释放的生长因子可募集修复细胞，并可能增强软组织修复。尽管目前临床证据有限，但由于其安全性以及新的门诊制备和输送设备的可用性，富含血小板血浆的使用有所增加。也有报道称其在手术中用于增强肩袖和跟腱修复。随着富含血小板血浆市场推广的增加，骨科医生必须了解现有的制备设备及其差异。许多对照临床试验正在进行，但在获得支持富含血小板血浆疗效的高级别临床证据之前，临床应用应谨慎对待。
