Romero F J, Segura-Aguilar J, Monsalve E, Hermenegildo C, Nies E, Puertas F J, Romá J
Departament de Fisiologia, Facultat de Medicina i Odontologia, Universitat de València, Spain.
Neurotoxicol Teratol. 1990 Nov-Dec;12(6):603-5. doi: 10.1016/0892-0362(90)90069-o.
The present work tries to establish the antioxidant capacity of the peripheral nervous tissue of the rat, in terms of the enzymatic activities present in this tissue that either prevent the formation of activated species as the semiquinone radical (DT-diaphorase), protect against activated oxygen species (superoxide dismutase, glutathione peroxidase), conjugate natural toxic products or xenobiotics (glutathione S-transferase, especially the activity conjugating 4-hydroxy-nonenal), or complete the glutathione system metabolism (glutathione disulfide reductase, gamma-glutamyl transpeptidase). All the activities studied are lower in this tissue than they are in liver, except for gamma-glutamyl transpeptidase. The relevance of the results obtained and its possible relationship with different neuropathies is discussed. It is concluded that the peripheral nervous tissue is by far less protected than the liver against oxidative damage.
本研究试图从大鼠外周神经组织中存在的酶活性方面来确定其抗氧化能力，这些酶活性包括防止形成诸如半醌自由基等活性物质（DT-黄递酶）、抵御活性氧（超氧化物歧化酶、谷胱甘肽过氧化物酶）、结合天然有毒产物或外源生物活性物质（谷胱甘肽S-转移酶，尤其是结合4-羟基壬烯醛的活性），或完成谷胱甘肽系统代谢（谷胱甘肽二硫化物还原酶、γ-谷氨酰转肽酶）。除γ-谷氨酰转肽酶外，该组织中所有研究的活性均低于肝脏中的活性。讨论了所得结果的相关性及其与不同神经病变的可能关系。得出的结论是，外周神经组织远比肝脏更易受到氧化损伤。
