Department of Electrical and Information Engineering, University of Oulu, Oulu, Finland.
Physiol Meas. 2009 Nov;30(11):1197-209. doi: 10.1088/0967-3334/30/11/005. Epub 2009 Oct 1.
A method to assess nasal airflow resistance is presented that provides a continuous resistance value and applies a novel minimally obtrusive measurement technique. Instead of calculating the resistance once for each breathing cycle conventionally, it is calculated for each signal sample at any sampling frequency. The continuous pressure recording is produced with a nasopharyngeal catheter inserted 8 cm deep along the floor of the other nasal cavity and the flow recording is produced with respiratory effort bands. A least-mean-square (LMS) extension for the resistance model of Broms is developed that dynamically adapts to the time-varying characteristics of the nasal functioning and produces the continuous resistance values. Experimental results are shown that demonstrate the uniqueness and applicability of the new technique in assessing quickly changing resistance in a histamine/xylometatsolin challenges, the differences between normal and symptomatic patients, and the effect of nasal treatment of patients.
本文提出了一种评估鼻腔气流阻力的方法，该方法提供了连续的阻力值，并采用了新颖的微创测量技术。与传统方法在每个呼吸周期计算一次阻力不同，该方法可以在任何采样频率下为每个信号样本计算阻力。连续压力记录是通过将鼻咽导管插入鼻腔底部 8 厘米深处获得的，流量记录则是通过呼吸努力带获得的。本文为 Broms 的阻力模型开发了最小均方（LMS）扩展，该扩展可以动态适应鼻腔功能的时变特性，并产生连续的阻力值。实验结果表明，该新技术在评估组织胺/二甲亚砜激发试验中快速变化的阻力、正常人和症状患者之间的差异以及患者的鼻腔治疗效果方面具有独特性和适用性。
