Department of Medical Physics and Bioengineering, University College London, Gower Street, London WC1E 6BT, UK.
Phys Med Biol. 2009 Oct 21;54(20):6277-86. doi: 10.1088/0031-9155/54/20/016. Epub 2009 Oct 1.
A solid dynamic phantom with tissue-like optical properties is presented, which contains seven discrete targets impregnated with thermochromic pigment located at different depths from the surface. Changes in absorption are obtained in response to localized heating of the targets, simulating haemodynamic changes occurring in the brain and other tissues. The depth sensitivity of a continuous wave optical topography system was assessed successfully using the phantom. Images of the targets have been reconstructed using a spatially variant regularization, and the determined spatial localization in the depth direction is shown to be accurate within an uncertainty of about 3 mm down to a depth of about 30 mm.
本文提出了一种具有组织样光学特性的固态动态体模，其中包含七个位于表面不同深度的离散目标，这些目标中浸渍有热变色颜料。通过对目标的局部加热来获得吸收变化，从而模拟大脑和其他组织中发生的血液动力学变化。成功地使用该体模评估了连续波光学层析成像系统的深度灵敏度。使用空间变分正则化重建了目标的图像，并显示在大约 30mm 的深度范围内，深度方向的确定空间定位精度约为 3mm。
